{"id":"i-v-sodium-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Metabolic alkalosis"},{"rate":null,"effect":"Phlebitis at injection site"},{"rate":null,"effect":"Fluid overload"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Sodium bicarbonate is a buffer that neutralizes excess hydrogen ions in the bloodstream, increasing serum pH and bicarbonate concentration. It is used to treat metabolic acidosis from various causes including renal failure, diabetic ketoacidosis, and drug overdoses. The alkalinizing effect can also enhance renal excretion of certain drugs and reduce hyperkalemia.","oneSentence":"Intravenous sodium bicarbonate raises blood pH and alkalinity to counteract metabolic acidosis and improve systemic acid-base balance.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:15:21.232Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metabolic acidosis"},{"name":"Diabetic ketoacidosis"},{"name":"Renal tubular acidosis"},{"name":"Drug overdose management (e.g., tricyclic antidepressants, aspirin)"}]},"trialDetails":[{"nctId":"NCT04891354","phase":"PHASE1","title":"A First-in-Human Study to Assess the Safety and Tolerability of PDNO","status":"COMPLETED","sponsor":"Attgeno AB","startDate":"2021-02-02","conditions":"Pulmonary Hypertension","enrollment":38},{"nctId":"NCT02980003","phase":"PHASE3","title":"PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization","status":"COMPLETED","sponsor":"G. d'Annunzio University","startDate":"2015-03","conditions":"Acute Kidney Injury, Contrast Media Reaction","enrollment":240},{"nctId":"NCT01098032","phase":"PHASE3","title":"RenalGuard System and Contrast Media","status":"COMPLETED","sponsor":"Clinica Mediterranea","startDate":"2009-01","conditions":"Chronic Kidney Disease","enrollment":294},{"nctId":"NCT01491243","phase":"PHASE4","title":"N-GAL Allows Intensive Treatment of Contrast Induced Nephropathy","status":"UNKNOWN","sponsor":"University of Roma La Sapienza","startDate":"2014-01","conditions":"Coronary Artery Disease","enrollment":100},{"nctId":"NCT00130598","phase":"PHASE2, PHASE3","title":"PROVOCATION Trial - PROphylactic intraVenOus Hydration for Contrast Agent Toxicity PreventION","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2005-06","conditions":"Kidney Failure, Acute","enrollment":258}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["HCO3"],"phase":"phase_3","status":"active","brandName":"i.v. sodium bicarbonate","genericName":"i.v. sodium bicarbonate","companyName":"G. d'Annunzio University","companyId":"g-d-annunzio-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous sodium bicarbonate raises blood pH and alkalinity to counteract metabolic acidosis and improve systemic acid-base balance. Used for Metabolic acidosis, Diabetic ketoacidosis, Renal tubular acidosis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}