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Hyperbaric bupivacaine+Sufentanil
Bupivacaine blocks sodium channels in nerve fibers to produce local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation; the hyperbaric formulation increases density for spinal distribution.
Bupivacaine blocks sodium channels in nerve fibers to produce local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation; the hyperbaric formulation increases density for spinal distribution. Used for Spinal anesthesia for surgical procedures, Postoperative pain management.
At a glance
| Generic name | Hyperbaric bupivacaine+Sufentanil |
|---|---|
| Also known as | Sufentanil |
| Sponsor | Fundación Pública Andaluza Progreso y Salud |
| Drug class | Local anesthetic + opioid combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu-opioid receptors (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that reversibly inhibits sodium influx in nerve membranes, preventing action potential propagation and sensory/motor blockade. Sufentanil is a potent synthetic opioid that binds mu-opioid receptors in the spinal cord and central nervous system to provide analgesia. The hyperbaric (dextrose-containing) formulation increases specific gravity, allowing controlled spread within cerebrospinal fluid for targeted spinal anesthesia.
Approved indications
- Spinal anesthesia for surgical procedures
- Postoperative pain management
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Respiratory depression
- Urinary retention
- Pruritus
Key clinical trials
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Norepinephrine in Caesarian Section (PHASE4)
- Intravenous Dexamethasone for Prolonging Sensory Block in Spinal Anesthesia (NA)
- Endoscopic Submucosal Dissection of Large Recto-sigmoid Lesions Under Spinal Anesthesia
- Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia (NA)
- Spinal Prilocaine for Caesarian Sections (NA)
- Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural (NA)
- Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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