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The hyperbaric (dextrose-containing) formulation increases specific gravity, allowing controlled spread within cerebrospinal fluid for targeted spinal anesthesia.","oneSentence":"Bupivacaine blocks sodium channels in nerve fibers to produce local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation; the hyperbaric formulation increases density for spinal distribution.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:43.317Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal anesthesia for surgical procedures"},{"name":"Postoperative pain management"}]},"trialDetails":[{"nctId":"NCT07377630","phase":"PHASE4","title":"Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Istituto Giannina Gaslini","startDate":"2026-03-01","conditions":"Pregnancy, Cesarean Section, Neuroaxial Analgesia Procedures","enrollment":100},{"nctId":"NCT05264870","phase":"PHASE4","title":"Norepinephrine in Caesarian Section","status":"TERMINATED","sponsor":"University Hospital, Antwerp","startDate":"2022-06-09","conditions":"Cesarean Section Complications, Hemodynamic Instability, Foetal Stress","enrollment":11},{"nctId":"NCT07088432","phase":"NA","title":"Intravenous Dexamethasone for Prolonging Sensory Block in Spinal Anesthesia","status":"COMPLETED","sponsor":"Tunis University","startDate":"2023-10-01","conditions":"Spinal Anesthesia, Postoperative Pain Management, Dexamethasone","enrollment":120},{"nctId":"NCT06316401","phase":"","title":"Endoscopic Submucosal Dissection of Large Recto-sigmoid Lesions Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Azienda USL Modena","startDate":"2021-01-01","conditions":"Colorectal (Colon or Rectal) Cancer","enrollment":20},{"nctId":"NCT05535036","phase":"NA","title":"Intravenous Dexamethasone Effectiveness in Post Caesarean Section Analgesia","status":"COMPLETED","sponsor":"Mongi Slim Hospital","startDate":"2020-02-10","conditions":"Cesarean Section, Dexamethasone, Postoperative Pain","enrollment":84},{"nctId":"NCT03219086","phase":"NA","title":"Spinal Prilocaine for Caesarian Sections","status":"COMPLETED","sponsor":"University Hospital, Antwerp","startDate":"2017-08-01","conditions":"Combined Spinal Epidural Anesthesia, Prilocaine, Bupivacaine","enrollment":182},{"nctId":"NCT02666794","phase":"NA","title":"Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2017-07-12","conditions":"Fetal Bradycardia, Hypertonic Uterine, Catecholamines","enrollment":50},{"nctId":"NCT04446715","phase":"NA","title":"Comparison of Meperidine and Sufentanil Added to 0.5% Hyperbaric Bupivacaine for Spinal Anesthesia in Cesarean Section","status":"UNKNOWN","sponsor":"Makassed General Hospital","startDate":"2020-10-01","conditions":"Analgesia","enrollment":60},{"nctId":"NCT03849508","phase":"PHASE4","title":"Phenylephrine Versus Norepinephrine for Maintenance of Hemodynamic During Cesarean Section Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Centre Hospitalier Régional d'Orléans","startDate":"2019-02-27","conditions":"Cesarean Section Complications, Spinal Anesthesia","enrollment":124},{"nctId":"NCT02973048","phase":"PHASE3","title":"Hyperbaric Bupivacaine Versus Hyperbaric Prilocaine 2% for Cesarean Section Under Spinal Anesthesia","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2018-03-12","conditions":"Pregnant Women, Pain, Hypotension","enrollment":40},{"nctId":"NCT03386630","phase":"PHASE4","title":"Effects of Analgesics in Cesarean Section Elective","status":"COMPLETED","sponsor":"Fundación Pública Andaluza Progreso y Salud","startDate":"2018-03-28","conditions":"Anesthesia; 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