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Hyalgan (sodium hyaluronate)
Sodium hyaluronate is a viscoelastic substance that lubricates and cushions joints by mimicking the properties of natural synovial fluid.
Sodium hyaluronate is a viscoelastic substance that lubricates and cushions joints by mimicking the properties of natural synovial fluid. Used for Osteoarthritis of the knee.
At a glance
| Generic name | Hyalgan (sodium hyaluronate) |
|---|---|
| Sponsor | Sanofi |
| Drug class | Viscosupplement |
| Target | Synovial fluid replacement (non-receptor mediated) |
| Modality | Small molecule |
| Therapeutic area | Rheumatology / Orthopedics |
| Phase | FDA-approved |
Mechanism of action
Hyaluronic acid is a naturally occurring polysaccharide found in synovial fluid that provides lubrication and shock absorption in joints. When injected intra-articularly, sodium hyaluronate restores the viscoelastic properties of degraded synovial fluid, reducing friction between cartilage surfaces and providing mechanical protection. This viscosupplementation approach helps alleviate pain and improve joint function in osteoarthritis.
Approved indications
- Osteoarthritis of the knee
Common side effects
- Injection site pain or swelling
- Transient joint effusion
- Local warmth or erythema
Key clinical trials
- USC-Exos in Corpus Spongiosum Reconstruction for Hypospadias (NA)
- Clinical Investigation on Lips Treated With HA-filler (NA)
- Using Different Biomaterials to Preserve Bone After Tooth Extraction (NA)
- Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy (NA)
- Early vs Delayed Intravesical Blad-Care During BCG Therapy (NA)
- A Clinical Investigation of the Decoria® Aesthetic Group (DAG) for Correction of Nasolabial Folds (NLF) (NA)
- Is Cross-linked Hyaluronic Acid a Biologic Alternative for Alveolar Ridge Preservation? (NA)
- A Post-market-clinical Follow-up Investigation of Safety and Performance by Decoria® Voluma (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hyalgan (sodium hyaluronate) CI brief — competitive landscape report
- Hyalgan (sodium hyaluronate) updates RSS · CI watch RSS
- Sanofi portfolio CI