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Honokiol
Honokiol is a Small molecule drug developed by The Methodist Hospital Research Institute. It is currently in Phase 1 development. Also known as: Honopure (Dietary supplement).
Honokiol is a small molecule lignan isolated from the bark, seed cones, and leaves of Magnolia trees, and it has been studied as a potential treatment for various conditions, including non-small-cell lung cancer, dental caries, acne vulgaris, gingival diseases, and HPV infection. It has been evaluated in clinical trials, including a Phase I trial for early-stage resectable non-small cell lung cancer, and has been administered through various methods, including chewing gum and cleanser.
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Baseline phase 1 → approval rate
+9.6pp
Industry-wide phase 1 drugs reach approval ~9.6% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
| Regulator | Country | Likely year | Lag vs FDA |
|---|---|---|---|
| FDA | US | 2033–2036 | — |
| EMA | EU | 2034–2037 | +0.7 yr |
| MHRA | GB | 2034–2037 | +0.7 yr |
| Health Canada | CA | 2034–2038 | +0.9 yr |
| TGA | AU | 2034–2038 | +1.2 yr |
| PMDA | JP | 2034–2038 | +1.5 yr |
| NMPA | CN | 2035–2039 | +2.3 yr |
| MFDS | KR | 2034–2038 | +1.4 yr |
| CDSCO | IN | 2034–2039 | +1.8 yr |
| ANVISA | BR | 2035–2039 | +2.3 yr |
Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).
Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.
At a glance
| Generic name | Honokiol |
|---|---|
| Also known as | Honopure (Dietary supplement) |
| Sponsor | The Methodist Hospital Research Institute |
| Modality | Small molecule |
| Therapeutic area | Other |
| Phase | Phase 1 |
Approved indications
Common side effects
Key clinical trials
- Clinical Trial to Evaluate Papilocare® Gel Efficacy Into Repairment of Cervical Lesions Caused by HPV (NA)
- 0.2% Chlorhexidine vs MicroRepair ABX in Gingivitis (NA)
- Comparison of 0.12% Chlorhexidine and MicroRepair ABX Mouthwash in Gingivitis Management (NA)
- Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer (PHASE1)
- The Effectiveness and Safety of Cleanser Containing Triethyl Citrate, Pyruvic Acid, Combination Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Salicylic Acid 0,5%, Zinc Lactate, Hyaluronic Acid and Spot Cream Containing Triethyl Citrate, Ethyl Linoleate, GT Peptide-10, Honokiol (PHASE3)
- A Clinical Study to Evaluate the Efficacy of Dietary Supplement to Alleviate Stress Versus Placebo in Subjects with Mild to Moderate Levels of Stress (NA)
- Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Caries Lesions in Healthy Adult Volunteers (NA)
- Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing. (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Honokiol CI brief — competitive landscape report
- Honokiol updates RSS · CI watch RSS
- The Methodist Hospital Research Institute portfolio CI
Frequently asked questions about Honokiol
What is Honokiol?
Who makes Honokiol?
Is Honokiol also known as anything else?
What development phase is Honokiol in?
Related
- Manufacturer: The Methodist Hospital Research Institute — full pipeline
- Therapeutic area: All drugs in Other
- Also known as: Honopure (Dietary supplement)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing