NCT02310308 is a NA clinical trial of Chewing gum administration in Dental Caries, sponsored by Università degli Studi di Sassari.

Who is sponsoring NCT02310308?

NCT02310308 is sponsored by Università degli Studi di Sassari.

What drugs are being tested in NCT02310308?

Interventions in NCT02310308: Chewing gum administration.

What condition does NCT02310308 study?

NCT02310308 studies Dental Caries.

Is NCT02310308 still recruiting?

NCT02310308 is currently status unknown. Last updated 5 December 2014.

Last reviewed 2014-12-05 · How we verify

NCT02310308

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of a Sugar-free Chewing Gum Containing Magnolia Bark Extract on the Development of Caries Lesions in Healthy Adult Volunteers: a Randomized Controlled Intervention Trial

Status unknown NA Last updated 5 December 2014

What this trial tests

NA trial testing Chewing gum administration in Dental Caries in 480 participants. Status unknown.

Timeline

1 April 2012

Primary endpoint
1 November 2014

1 November 2015

Quick facts

Lead sponsor	Università degli Studi di Sassari
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	480
Start date	1 April 2012
Primary completion	1 November 2014
Estimated completion	1 November 2015
Sites	2 locations across Italy

Drugs / interventions tested

Chewing gum administration

Conditions studied

Dental Caries — all drugs for Dental Caries →

Sponsor

Università degli Studi di Sassari

Who can join

Adults 30 to 45, any sex, with Dental Caries. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

International Caries Detection and Assessment System (ICDAS) increment
Time frame: 24 months
cumulative D2 or Filled Surface (D2 FS) increment (root and coronal surfaces combined).

Sponsor's own description

The effect of chewing gums containing MBE and xylitol on different variables related to caries and gingivitis in a sample of adult volunteers with a high risk for caries will be evaluated. The main result of that double-blind randomized controlled interventional trial will be that chewing gum containing MBE was more effective in reducing plaque acidogenicity, salivary mutans streptococci concentration and gingival bleeding compared to a xylitol and sugar-free chewing gum.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults.
Cocco F, Carta G, Cagetti MG, Strohmenger L, et al · · 2017 · cited 19× · PMID 28303470 · DOI 10.1007/s00784-017-2075-5

Verify or expand the search:

Other recruiting trials for Dental Caries

Currently open trials in the same condition.

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NCT07134114 — Occlusal Impact of Hall Crowns in Primary Molars · NA · recruiting
NCT07181967 — SDF vs Fluoride Varnish for Streptococcus Mutans Reduction in Children · NA · recruiting

Other Università degli Studi di Sassari trials

Trials by the same sponsor.

NCT06276712 — RCT Comparing KS Versus TS for Ovedenture · NA · not yet recruiting
NCT06286579 — SOI Immediately vs Delayed · NA · not yet recruiting
NCT06286605 — RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A · NA · not yet recruiting
NCT06286566 — Soi TS3 Surface in Patients With and Without Type 2 Diabetes · NA · not yet recruiting
NCT05843981 — Comparison KS Versus TS · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02310308 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Università degli Studi di Sassari
Last refreshed: 5 December 2014

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02310308.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing