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High Dose Clomiphencitrat
Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and stimulating ovulation or spermatogenesis.
Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and stimulating ovulation or spermatogenesis. Used for Anovulation and infertility in women, Male infertility and hypogonadism.
At a glance
| Generic name | High Dose Clomiphencitrat |
|---|---|
| Sponsor | University Hospital, Basel, Switzerland |
| Drug class | Selective estrogen receptor modulator (SERM) |
| Target | Estrogen receptor (ER-α and ER-β) |
| Modality | Small molecule |
| Therapeutic area | Reproductive endocrinology / Fertility |
| Phase | FDA-approved |
Mechanism of action
Clomiphene acts as a competitive antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback that estrogen exerts on GnRH and gonadotropin release. This disinhibition leads to increased FSH and LH secretion, which stimulates follicle development in women and testosterone production in men. The high-dose formulation may be used to overcome resistance or achieve enhanced gonadotropin stimulation in certain patient populations.
Approved indications
- Anovulation and infertility in women
- Male infertility and hypogonadism
Common side effects
- Hot flashes
- Ovarian hyperstimulation syndrome (OHSS)
- Abdominal discomfort or bloating
- Nausea
- Visual disturbances
- Headache
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- High Dose Clomiphencitrat CI brief — competitive landscape report
- High Dose Clomiphencitrat updates RSS · CI watch RSS
- University Hospital, Basel, Switzerland portfolio CI