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High Dose Clomiphencitrat — Competitive Intelligence Brief
marketed
Selective estrogen receptor modulator (SERM)
Estrogen receptor (ER-α and ER-β)
Reproductive endocrinology / Fertility
Small molecule
Live · refreshed every 30 min
Target snapshot
High Dose Clomiphencitrat (High Dose Clomiphencitrat) — University Hospital, Basel, Switzerland. Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and stimulating ovulation or spermatogenesis.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| High Dose Clomiphencitrat TARGET | High Dose Clomiphencitrat | University Hospital, Basel, Switzerland | marketed | Selective estrogen receptor modulator (SERM) | Estrogen receptor (ER-α and ER-β) | |
| Toremifene; Anastrozole | Toremifene; Anastrozole | Peking Union Medical College Hospital | marketed | Selective estrogen receptor modulator (SERM) + aromatase inhibitor (AI) | Estrogen receptor (ER); aromatase (CYP19A1) | |
| Tamoxifen Oral Tablet | Tamoxifen Oral Tablet | Samsung Medical Center | marketed | Selective estrogen receptor modulator (SERM) | Estrogen receptor alpha (ERα) | |
| fenofibrate and tibolone | fenofibrate and tibolone | Keogh Institute for Medical Research | marketed | Fibrate + Selective Estrogen Receptor Modulator (SERM) | PPAR-α (fenofibrate); Estrogen receptor, progesterone receptor, androgen receptor (tibolone) | |
| raloxifene HCI and alendronate Na | raloxifene HCI and alendronate Na | Eli Lilly and Company | marketed | Selective estrogen receptor modulator (SERM) + bisphosphonate combination | Estrogen receptor (raloxifene); osteoclast farnesyl pyrophosphate synthase (alendronate) | |
| Low Dose Clomiphencitrat | Low Dose Clomiphencitrat | University Hospital, Basel, Switzerland | marketed | Selective estrogen receptor modulator (SERM) | Estrogen receptor (ER-α and ER-β) | |
| Bazedoxifene/Conjugated Estrogen | Bazedoxifene/Conjugated Estrogen | University of North Carolina, Chapel Hill | marketed | Selective Estrogen Receptor Modulator (SERM) combined with Conjugated Estrogens | Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Selective estrogen receptor modulator (SERM) class)
- University Hospital, Basel, Switzerland · 2 drugs in this class
- AstraZeneca · 2 drugs in this class
- Estetra · 1 drug in this class
- Fundació Privada Eugin · 1 drug in this class
- H. Lee Moffitt Cancer Center and Research Institute · 1 drug in this class
- National Taiwan University Hospital · 1 drug in this class
- Oregon Health and Science University · 1 drug in this class
- Samsung Medical Center · 1 drug in this class
- Shandong Suncadia Medicine Co., Ltd. · 1 drug in this class
- Sheba Medical Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). High Dose Clomiphencitrat — Competitive Intelligence Brief. https://druglandscape.com/ci/high-dose-clomiphencitrat. Accessed 2026-05-17.
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