{"id":"high-dose-clomiphencitrat","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Hot flashes"},{"rate":"1-2","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5-15","effect":"Abdominal discomfort or bloating"},{"rate":"5-10","effect":"Nausea"},{"rate":"1-3","effect":"Visual disturbances"},{"rate":"5-10","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clomiphene acts as a competitive antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback that estrogen exerts on GnRH and gonadotropin release. This disinhibition leads to increased FSH and LH secretion, which stimulates follicle development in women and testosterone production in men. The high-dose formulation may be used to overcome resistance or achieve enhanced gonadotropin stimulation in certain patient populations.","oneSentence":"Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and stimulating ovulation or spermatogenesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:47:49.489Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anovulation and infertility in women"},{"name":"Male infertility and hypogonadism"}]},"trialDetails":[{"nctId":"NCT01577472","phase":"PHASE4","title":"Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2013-08","conditions":"Female Infertility, Ovarian Insufficiency","enrollment":117}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"High Dose Clomiphencitrat","genericName":"High Dose Clomiphencitrat","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clomiphene citrate is a selective estrogen receptor modulator (SERM) that blocks negative feedback of estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and stimulating ovulation or spermatogenesis. Used for Anovulation and infertility in women, Male infertility and hypogonadism.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}