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GSK1755165; placebo; zopiclone
GSK1755165; placebo; zopiclone is a Non-benzodiazepine hypnotic (Z-drug) Small molecule drug developed by GlaxoSmithKline. It is currently in Phase 3 development for Insomnia (sleep initiation and/or maintenance).
GSK1755165 is a selective GABA-A receptor modulator that enhances inhibitory neurotransmission to promote sleep.
GSK1755165 is a selective GABA-A receptor modulator that enhances inhibitory neurotransmission to promote sleep. Used for Insomnia (sleep initiation and/or maintenance).
At a glance
| Generic name | GSK1755165; placebo; zopiclone |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Non-benzodiazepine hypnotic (Z-drug) |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Neurology / Sleep Medicine |
| Phase | Phase 3 |
Mechanism of action
GSK1755165 binds to and potentiates GABA-A receptors, increasing the frequency of chloride channel opening and enhancing GABAergic inhibitory signaling in the central nervous system. This mechanism is similar to other Z-drugs like zopiclone (the comparator in this trial), but GSK1755165 was designed with improved selectivity and potentially better tolerability. The drug promotes sleep onset and maintenance through enhanced neuronal inhibition.
Approved indications
- Insomnia (sleep initiation and/or maintenance)
Common side effects
- Headache
- Dizziness
- Somnolence
- Nausea
- Fatigue
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- GSK1755165; placebo; zopiclone CI brief — competitive landscape report
- GSK1755165; placebo; zopiclone updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
Frequently asked questions about GSK1755165; placebo; zopiclone
What is GSK1755165; placebo; zopiclone?
How does GSK1755165; placebo; zopiclone work?
What is GSK1755165; placebo; zopiclone used for?
Who makes GSK1755165; placebo; zopiclone?
What drug class is GSK1755165; placebo; zopiclone in?
What development phase is GSK1755165; placebo; zopiclone in?
What are the side effects of GSK1755165; placebo; zopiclone?
What does GSK1755165; placebo; zopiclone target?
Related
- Drug class: All Non-benzodiazepine hypnotic (Z-drug) drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Neurology / Sleep Medicine
- Indication: Drugs for Insomnia (sleep initiation and/or maintenance)
- Compare: GSK1755165; placebo; zopiclone vs similar drugs
- Pricing: GSK1755165; placebo; zopiclone cost, discount & access