{"id":"gsk1755165-placebo-zopiclone","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"}]},"_chembl":{"chemblId":"CHEMBL135400","moleculeType":"Small molecule","molecularWeight":"388.82"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"GSK1755165 binds to and potentiates GABA-A receptors, increasing the frequency of chloride channel opening and enhancing GABAergic inhibitory signaling in the central nervous system. This mechanism is similar to other Z-drugs like zopiclone (the comparator in this trial), but GSK1755165 was designed with improved selectivity and potentially better tolerability. The drug promotes sleep onset and maintenance through enhanced neuronal inhibition.","oneSentence":"GSK1755165 is a selective GABA-A receptor modulator that enhances inhibitory neurotransmission to promote sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:33.783Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia (sleep initiation and/or maintenance)"}]},"trialDetails":[{"nctId":"NCT00699608","phase":"PHASE3","title":"An Evaluation of Potential Next-day Residual Effects of Eszopiclone in Healthy Volunteers.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-07","conditions":"Healthy Subjects, Sleep Initiation and Maintenance Disorders","enrollment":91}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":231,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"GSK1755165; placebo; zopiclone","genericName":"GSK1755165; placebo; zopiclone","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"GSK1755165 is a selective GABA-A receptor modulator that enhances inhibitory neurotransmission to promote sleep. Used for Insomnia (sleep initiation and/or maintenance).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}