Last reviewed · How we verify
Gabapentin + dexamethasone + ketamine
This combination uses gabapentin to modulate neuropathic pain, dexamethasone to reduce inflammation, and ketamine to provide rapid-onset analgesia and anesthesia through NMDA receptor antagonism.
This combination uses gabapentin to modulate neuropathic pain, dexamethasone to reduce inflammation, and ketamine to provide rapid-onset analgesia and anesthesia through NMDA receptor antagonism. Used for Acute and chronic pain management in hospital/clinical settings, Procedural sedation and analgesia.
At a glance
| Generic name | Gabapentin + dexamethasone + ketamine |
|---|---|
| Also known as | Anti-hyperalgesics, Postoperative pain |
| Sponsor | Glostrup University Hospital, Copenhagen |
| Drug class | Combination therapy (anticonvulsant + corticosteroid + dissociative anesthetic) |
| Target | Alpha-2-delta calcium channel subunit (gabapentin); glucocorticoid receptor (dexamethasone); NMDA receptor (ketamine) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing neurotransmitter release in neuropathic pain pathways. Dexamethasone is a corticosteroid that suppresses inflammatory responses. Ketamine acts as a non-competitive NMDA receptor antagonist, providing dissociative anesthesia and analgesia, particularly useful in acute pain management and procedural sedation.
Approved indications
- Acute and chronic pain management in hospital/clinical settings
- Procedural sedation and analgesia
Common side effects
- Dizziness
- Sedation
- Dissociation
- Hyperglycemia (dexamethasone)
- Immunosuppression (dexamethasone)
Key clinical trials
- Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery (PHASE3)
- A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy (PHASE4)
- A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery (NA)
- Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy (PHASE3)
- ACL Repair and Multimodal Analgesia (PHASE4)
- IPACK Nerve Block for Total Knee Arthroplasty (PHASE4)
- Pre-Emptive Analgesia in Ano-Rectal Surgery (NA)
- The Effect of Gabapentin, Ketamine and Dexamethasone on Pain and Opioid Requirements After Hip Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: