{"id":"gabapentin-dexamethasone-ketamine","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Hyperglycemia (dexamethasone)"},{"rate":null,"effect":"Immunosuppression (dexamethasone)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Gabapentin binds to the alpha-2-delta subunit of voltage-gated calcium channels, reducing neurotransmitter release in neuropathic pain pathways. Dexamethasone is a corticosteroid that suppresses inflammatory responses. Ketamine acts as a non-competitive NMDA receptor antagonist, providing dissociative anesthesia and analgesia, particularly useful in acute pain management and procedural sedation.","oneSentence":"This combination uses gabapentin to modulate neuropathic pain, dexamethasone to reduce inflammation, and ketamine to provide rapid-onset analgesia and anesthesia through NMDA receptor antagonism.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:39:54.989Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute and chronic pain management in hospital/clinical settings"},{"name":"Procedural sedation and analgesia"}]},"trialDetails":[{"nctId":"NCT04144933","phase":"PHASE3","title":"Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Saskatchewan","startDate":"2021-05-15","conditions":"Anesthesia, General Anesthesia, Analgesics, Opioid","enrollment":60},{"nctId":"NCT05200806","phase":"PHASE4","title":"A Prospective Pilot Study of a Non-Narcotic Post-Operative Course After Colectomy","status":"UNKNOWN","sponsor":"University of Vermont","startDate":"2022-02-07","conditions":"Analgesia, Post-Operative Pain, Breakthrough Pain","enrollment":25},{"nctId":"NCT05312541","phase":"NA","title":"A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2022-04-10","conditions":"Opioid Free Anesthesia","enrollment":74},{"nctId":"NCT02987985","phase":"PHASE3","title":"Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2017-10-15","conditions":"Anesthesia, General Anesthesia, Analgesics, Opioid","enrollment":50},{"nctId":"NCT01868425","phase":"PHASE4","title":"ACL Repair and Multimodal Analgesia","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2013-04","conditions":"Pain","enrollment":112},{"nctId":"NCT03921034","phase":"PHASE4","title":"IPACK Nerve Block for Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Ochsner Health System","startDate":"2016-11-17","conditions":"Arthropathy of Knee, Anesthesia","enrollment":72},{"nctId":"NCT02402543","phase":"NA","title":"Pre-Emptive Analgesia in Ano-Rectal Surgery","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2014-06","conditions":"Hemorrhoids, Fissure in Ano, Rectal Fistula","enrollment":90},{"nctId":"NCT00236223","phase":"PHASE4","title":"The Effect of Gabapentin, Ketamine and Dexamethasone on Pain and Opioid Requirements After Hip Surgery","status":"TERMINATED","sponsor":"Glostrup University Hospital, Copenhagen","startDate":"2005-10","conditions":"Pain, Postoperative","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Anti-hyperalgesics","Postoperative pain"],"phase":"marketed","status":"active","brandName":"Gabapentin + dexamethasone + ketamine","genericName":"Gabapentin + dexamethasone + ketamine","companyName":"Glostrup University Hospital, Copenhagen","companyId":"glostrup-university-hospital-copenhagen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses gabapentin to modulate neuropathic pain, dexamethasone to reduce inflammation, and ketamine to provide rapid-onset analgesia and anesthesia through NMDA receptor antagonism. Used for Acute and chronic pain management in hospital/clinical settings, Procedural sedation and analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}