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Famotidine (FAM)

Bristol-Myers Squibb · FDA-approved active Small molecule

Famotidine (FAM) is a H2-receptor antagonist Small molecule drug developed by Bristol-Myers Squibb. It is currently FDA-approved for Duodenal ulcer, Gastric ulcer, Gastroesophageal reflux disease (GERD).

Famotidine is a histamine H2-receptor antagonist that reduces gastric acid secretion by blocking histamine-mediated stimulation of parietal cells in the stomach.

Famotidine is a histamine H2-receptor antagonist that reduces gastric acid secretion by blocking histamine-mediated stimulation of parietal cells in the stomach. Used for Duodenal ulcer, Gastric ulcer, Gastroesophageal reflux disease (GERD).

At a glance

Generic nameFamotidine (FAM)
SponsorBristol-Myers Squibb
Drug classH2-receptor antagonist
TargetHistamine H2 receptor
ModalitySmall molecule
Therapeutic areaGastroenterology
PhaseFDA-approved

Mechanism of action

Famotidine competitively inhibits histamine binding to H2 receptors on gastric parietal cells, thereby decreasing both basal and stimulated gastric acid production. This reduction in acid secretion provides symptomatic relief and promotes healing of acid-related gastrointestinal lesions. It is more potent and longer-acting than earlier H2-receptor antagonists like cimetidine.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Famotidine (FAM)

What is Famotidine (FAM)?

Famotidine (FAM) is a H2-receptor antagonist drug developed by Bristol-Myers Squibb, indicated for Duodenal ulcer, Gastric ulcer, Gastroesophageal reflux disease (GERD).

How does Famotidine (FAM) work?

Famotidine is a histamine H2-receptor antagonist that reduces gastric acid secretion by blocking histamine-mediated stimulation of parietal cells in the stomach.

What is Famotidine (FAM) used for?

Famotidine (FAM) is indicated for Duodenal ulcer, Gastric ulcer, Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, Peptic ulcer disease prophylaxis.

Who makes Famotidine (FAM)?

Famotidine (FAM) is developed and marketed by Bristol-Myers Squibb (see full Bristol-Myers Squibb pipeline at /company/bristol-myers-squibb).

What drug class is Famotidine (FAM) in?

Famotidine (FAM) belongs to the H2-receptor antagonist class. See all H2-receptor antagonist drugs at /class/h2-receptor-antagonist.

What development phase is Famotidine (FAM) in?

Famotidine (FAM) is FDA-approved (marketed).

What are the side effects of Famotidine (FAM)?

Common side effects of Famotidine (FAM) include Headache, Dizziness, Constipation, Diarrhea, Fatigue.

What does Famotidine (FAM) target?

Famotidine (FAM) targets Histamine H2 receptor and is a H2-receptor antagonist.

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