Last reviewed · How we verify
Essential oils mouthrinse
Essential oils mouthrinse exerts antimicrobial and anti-inflammatory effects in the oral cavity through volatile aromatic compounds.
Essential oils mouthrinse exerts antimicrobial and anti-inflammatory effects in the oral cavity through volatile aromatic compounds. Used for Oral hygiene and plaque control, Gingivitis prevention and treatment.
At a glance
| Generic name | Essential oils mouthrinse |
|---|---|
| Also known as | Listerine Cool Mint |
| Sponsor | University of Lisbon |
| Drug class | Herbal/botanical antimicrobial mouthrinse |
| Modality | Small molecule |
| Therapeutic area | Dentistry/Oral Health |
| Phase | Phase 3 |
Mechanism of action
Essential oils contain bioactive constituents (such as terpenes, phenols, and aldehydes) that demonstrate broad-spectrum antimicrobial activity against oral pathogens and reduce inflammation of oral tissues. When formulated as a mouthrinse, these compounds help control bacterial biofilm formation, reduce plaque accumulation, and promote gingival health through local topical application.
Approved indications
- Oral hygiene and plaque control
- Gingivitis prevention and treatment
Common side effects
- Oral irritation or burning sensation
- Allergic reaction to essential oil components
- Taste alteration
Key clinical trials
- To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. (NA)
- Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction (PHASE3)
- Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation (NA)
- Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care (PHASE4)
- A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen (NA)
- Evaluation of Antiplaque Efficacy of Licorice Extract Mouthrinse & HSS and Their Comparison With EO & CHX Mouthrinse (NA)
- Alcohol-free Essential Oils Containing Mouthrinse Efficacy on 3-day Supragingival Plaque Regrowth (NA)
- Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Essential oils mouthrinse CI brief — competitive landscape report
- Essential oils mouthrinse updates RSS · CI watch RSS
- University of Lisbon portfolio CI