{"id":"essential-oils-mouthrinse","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or burning sensation"},{"rate":null,"effect":"Allergic reaction to essential oil components"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":{"chemblId":"CHEMBL1201485","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Essential oils contain bioactive constituents (such as terpenes, phenols, and aldehydes) that demonstrate broad-spectrum antimicrobial activity against oral pathogens and reduce inflammation of oral tissues. When formulated as a mouthrinse, these compounds help control bacterial biofilm formation, reduce plaque accumulation, and promote gingival health through local topical application.","oneSentence":"Essential oils mouthrinse exerts antimicrobial and anti-inflammatory effects in the oral cavity through volatile aromatic compounds.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:11:36.816Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral hygiene and plaque control"},{"name":"Gingivitis prevention and treatment"}]},"trialDetails":[{"nctId":"NCT07191262","phase":"NA","title":"To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse.","status":"RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-03-02","conditions":"Extraction Sites After Removal and Bone Replacement Grafting at Extraction Sockets of Dentally Hopeless Single-rooted Teeth","enrollment":40},{"nctId":"NCT06607263","phase":"PHASE3","title":"Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis Reduction","status":"COMPLETED","sponsor":"Colgate Palmolive","startDate":"2024-09-16","conditions":"Gingival Bleeding, Plaque Induced Gingival Disease, Gingivitis and Periodontal Diseases","enrollment":120},{"nctId":"NCT01236963","phase":"NA","title":"Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation","status":"COMPLETED","sponsor":"University of Lisbon","startDate":"2007-09","conditions":"Gingivitis, Dental Plaque Accumulation","enrollment":60},{"nctId":"NCT01195493","phase":"PHASE4","title":"Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2010-03","conditions":"Chronic Periodontitis","enrollment":50},{"nctId":"NCT01419626","phase":"NA","title":"A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2011-07-31","conditions":"Gingivitis","enrollment":140},{"nctId":"NCT03550651","phase":"NA","title":"Evaluation of Antiplaque Efficacy of Licorice Extract Mouthrinse & HSS and Their Comparison With EO & CHX Mouthrinse","status":"COMPLETED","sponsor":"Government College of Dentistry, Indore","startDate":"2016-08","conditions":"Mild Gingivitis, Periodontal Diseases, Plaque","enrollment":35},{"nctId":"NCT02894593","phase":"NA","title":"Alcohol-free Essential Oils Containing Mouthrinse Efficacy on 3-day Supragingival Plaque Regrowth","status":"COMPLETED","sponsor":"University of L'Aquila","startDate":"2015-01","conditions":"Gingivitis, Periodontitis","enrollment":21},{"nctId":"NCT02980497","phase":"NA","title":"Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2013-09","conditions":"Plaque, Gingivitis, Gum Inflammation","enrollment":370},{"nctId":"NCT01637948","phase":"PHASE1","title":"Controlled Clinical Trial of Traditional Chinese Medicine Mouthrinse","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2010-10","conditions":"Gingivitis","enrollment":90},{"nctId":"NCT01236950","phase":"NA","title":"Study of an Essential Oil and a Delmopinol Mouthrinse Effect on Dental Plaque Accumulation Index, Gingivitis Index and on Streptococcus Mutans, Lactobacillus, Aerobic and Anaerobic Oral Bacteria Colony Counts.","status":"COMPLETED","sponsor":"University of Lisbon","startDate":"2007-04","conditions":"Gingivitis, Dental Plaque Accumulation","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":119,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Listerine Cool Mint"],"phase":"phase_3","status":"active","brandName":"Essential oils mouthrinse","genericName":"Essential oils mouthrinse","companyName":"University of Lisbon","companyId":"university-of-lisbon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Essential oils mouthrinse exerts antimicrobial and anti-inflammatory effects in the oral cavity through volatile aromatic compounds. Used for Oral hygiene and plaque control, Gingivitis prevention and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}