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DXM + Propofol
DXM (dextromethorphan) and propofol together provide dissociative anesthesia and analgesia through NMDA receptor antagonism and GABAergic potentiation.
DXM (dextromethorphan) and propofol together provide dissociative anesthesia and analgesia through NMDA receptor antagonism and GABAergic potentiation. Used for Anesthesia induction and maintenance (investigational combination).
At a glance
| Generic name | DXM + Propofol |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Dissociative anesthetic combination |
| Target | NMDA receptor (DXM); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Dextromethorphan is a non-competitive NMDA receptor antagonist that produces dissociative effects and analgesia. Propofol is a GABAergic agent that enhances inhibitory neurotransmission, producing sedation and hypnosis. The combination leverages complementary mechanisms for anesthetic and analgesic effects, potentially reducing required doses of each agent.
Approved indications
- Anesthesia induction and maintenance (investigational combination)
Common side effects
- Respiratory depression
- Hypotension
- Dissociative effects
- Emergence delirium
Key clinical trials
- Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery (NA)
- Effect of Ketorolac on Post Adenotonsillectomy Pain (PHASE4)
- PROUD Study - Preventing Opioid Use Disorders (PHASE4)
- Lumbar Erector Spinae Plane Block for Back Surgery (PHASE3)
- Opioid Free Anesthesia vs. Opioid Anesthesia Techniques. (PHASE2, PHASE3)
- The Effect of Propofol on Dexamethasone-induced Perineal Pruritus (EARLY_PHASE1)
- Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis (PHASE3)
- Inhibitory Effect of Propofol on Perineal Pruritus in Patients Undergoing Day Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- DXM + Propofol CI brief — competitive landscape report
- DXM + Propofol updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI