{"id":"dxm-propofol","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Dissociative effects"},{"rate":null,"effect":"Emergence delirium"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dextromethorphan is a non-competitive NMDA receptor antagonist that produces dissociative effects and analgesia. Propofol is a GABAergic agent that enhances inhibitory neurotransmission, producing sedation and hypnosis. The combination leverages complementary mechanisms for anesthetic and analgesic effects, potentially reducing required doses of each agent.","oneSentence":"DXM (dextromethorphan) and propofol together provide dissociative anesthesia and analgesia through NMDA receptor antagonism and GABAergic potentiation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:31:53.906Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance (investigational combination)"}]},"trialDetails":[{"nctId":"NCT06835010","phase":"NA","title":"Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-05-20","conditions":"AKI - Acute Kidney Injury","enrollment":90},{"nctId":"NCT03467750","phase":"PHASE4","title":"Effect of Ketorolac on Post Adenotonsillectomy Pain","status":"COMPLETED","sponsor":"Emory University","startDate":"2018-07-19","conditions":"Obstructive Sleep Apnea","enrollment":63},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57},{"nctId":"NCT03825198","phase":"PHASE3","title":"Lumbar Erector Spinae Plane Block for Back Surgery","status":"UNKNOWN","sponsor":"Dr M. B. Breebaart","startDate":"2019-08-01","conditions":"Pain, Postoperative, Anaesthesia, Surgery","enrollment":80},{"nctId":"NCT03367988","phase":"PHASE2, PHASE3","title":"Opioid Free Anesthesia vs. Opioid Anesthesia Techniques.","status":"UNKNOWN","sponsor":"University of South Florida","startDate":"2018-12-01","conditions":"Analgesic Drug Dependence, Colectomy","enrollment":100},{"nctId":"NCT04337073","phase":"EARLY_PHASE1","title":"The Effect of Propofol on Dexamethasone-induced Perineal Pruritus","status":"COMPLETED","sponsor":"Yangzhou University","startDate":"2020-09-01","conditions":"Pruritus","enrollment":40},{"nctId":"NCT02740127","phase":"PHASE3","title":"Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2016-06","conditions":"Malignant Neoplasms of Male Genital Organs","enrollment":52},{"nctId":"NCT05162430","phase":"NA","title":"Inhibitory Effect of Propofol on Perineal Pruritus in Patients Undergoing Day Surgery","status":"COMPLETED","sponsor":"Yangzhou University","startDate":"2021-01-20","conditions":"Pruritus Vulvae","enrollment":150},{"nctId":"NCT02102139","phase":"PHASE4","title":"Preop Dexmedetomidine Attenuates Haemodynamic Responses to Hydrodissection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2012-05","conditions":"Robotic Thyroidectomy","enrollment":41}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"DXM + Propofol","genericName":"DXM + Propofol","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"DXM (dextromethorphan) and propofol together provide dissociative anesthesia and analgesia through NMDA receptor antagonism and GABAergic potentiation. Used for Anesthesia induction and maintenance (investigational combination).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}