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DXM + Propofol — Competitive Intelligence Brief
marketed
Dissociative anesthetic combination
NMDA receptor (DXM); GABA-A receptor (propofol)
Anesthesia
Small molecule
Live · refreshed every 30 min
Target snapshot
DXM + Propofol (DXM + Propofol) — Seoul National University Hospital. DXM (dextromethorphan) and propofol together provide dissociative anesthesia and analgesia through NMDA receptor antagonism and GABAergic potentiation.
Comparator set (2 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| DXM + Propofol TARGET | DXM + Propofol | Seoul National University Hospital | marketed | Dissociative anesthetic combination | NMDA receptor (DXM); GABA-A receptor (propofol) | |
| Midazolam+Ketamine Combination | Midazolam+Ketamine Combination | Universidad de Cartagena | marketed | Sedative-hypnotic and dissociative anesthetic combination | GABA-A receptor (midazolam); NMDA receptor (ketamine) | |
| Haloperidol + Ketamine | Haloperidol + Ketamine | University Hospital, Basel, Switzerland | marketed | Antipsychotic + Dissociative anesthetic combination | Dopamine D2 receptor (haloperidol); NMDA glutamate receptor (ketamine) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Dissociative anesthetic combination class)
- Seoul National University Hospital · 1 drug in this class
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Cite this brief
Drug Landscape (2026). DXM + Propofol — Competitive Intelligence Brief. https://druglandscape.com/ci/dxm-propofol. Accessed 2026-05-14.
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