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Midazolam+Ketamine Combination
Midazolam and ketamine together produce sedation and anesthesia by enhancing GABAergic inhibition and blocking NMDA glutamate receptors, respectively.
Midazolam and ketamine together provide sedation and anesthesia by enhancing GABAergic inhibition and blocking NMDA receptors, respectively. Used for Procedural sedation and anesthesia, Emergency sedation, Induction of general anesthesia.
At a glance
| Generic name | Midazolam+Ketamine Combination |
|---|---|
| Also known as | Midazolam, Ketamine hydrochloride |
| Sponsor | Universidad de Cartagena |
| Drug class | Sedative-hypnotic and dissociative anesthetic combination |
| Target | GABA-A receptor (midazolam); NMDA receptor (ketamine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Sedation |
| Phase | FDA-approved |
Mechanism of action
Midazolam is a benzodiazepine that potentiates GABA-A receptor signaling in the central nervous system, producing anxiolysis and sedation. Ketamine is an NMDA receptor antagonist that produces dissociative anesthesia and analgesia. The combination leverages synergistic effects for enhanced sedation and anesthesia with potentially reduced individual drug requirements.
Approved indications
- Procedural sedation and anesthesia
- Emergency medicine sedation
Common side effects
- Respiratory depression
- Hypotension
- Emergence reactions (ketamine)
- Dizziness
- Drowsiness
Key clinical trials
- Ketamine, SGB and Combination Treatment for TBI (PHASE2)
- Prospective IR-led Sedation Feasibility (PHASE1, PHASE2)
- Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery (NA)
- Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology (EARLY_PHASE1)
- The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain. (EARLY_PHASE1)
- The Effects of Sedatives on Tobacco Use Disorder Version 2 (EARLY_PHASE1)
- Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures (PHASE4)
- Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |