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CZP
CZP is a humanized monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling.
CZP is a humanized monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling. Used for Rheumatoid arthritis, Crohn's disease, Psoriatic arthritis.
At a glance
| Generic name | CZP |
|---|---|
| Also known as | CDP870, certolizumab pegol, Cimzia® |
| Sponsor | Astellas Pharma Inc |
| Drug class | TNF-α inhibitor |
| Target | TNF-α (Tumor Necrosis Factor-alpha) |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
CZP (certolizumab pegol) is a TNF-α inhibitor that works by binding to soluble and membrane-bound TNF-α, preventing its interaction with TNF receptors on immune cells. This blocks the inflammatory cascade driven by TNF-α, reducing systemic inflammation and immune activation. It is a pegylated Fab fragment of a humanized monoclonal antibody, which may offer pharmacokinetic advantages over full-length antibodies.
Approved indications
- Rheumatoid arthritis
- Crohn's disease
- Psoriatic arthritis
- Ankylosing spondylitis
- Non-radiographic axial spondyloarthritis
Common side effects
- Infections (including serious infections)
- Injection site reactions
- Upper respiratory tract infections
- Headache
- Tuberculosis reactivation risk
Key clinical trials
- A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis (PHASE3)
- Biologic Treatment Withdrawal in Takayasu Arteritis Patients in Sustained Remission (NA)
- Stand UP to Rheumatoid Arthritis (SUPRA) (NA)
- Lipids, Inflammation, and CV Risk in RA
- Utilization of a Microdevice for Psoriasis and Atopic Dermatitis (PHASE4)
- Adding Certolizumab to Chemotherapy + Nivolumab in People Who Have Lung Cancer That Can Be Treated With Surgery (PHASE2)
- A Study to Evaluate the Nipocalimab and Certolizumab Combination Therapy in Participants With Active Rheumatoid Arthritis (PHASE2)
- The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- CZP CI brief — competitive landscape report
- CZP updates RSS · CI watch RSS
- Astellas Pharma Inc portfolio CI