Astellas Pharma Inc

Quick facts

Marketed products

• AST-120 (Kremezin®) · Nephrology
  AST-120 is an oral adsorbent that binds uremic toxins and other waste products in the gastrointestinal tract to reduce their systemic absorption and accumulation.
• Corticosteroids (Prednisone) · Immunology, Rheumatology, Oncology, Endocrinology, Gastroenterology
  Prednisone is a corticosteroid that binds to glucocorticoid receptors in the cytoplasm, translocates to the nucleus, and suppresses inflammatory gene expression and immune cell activation.
• cyclosporine microemulsion
• Fluticasone 0.005% · Dermatology
  Fluticasone is a corticosteroid that suppresses local immune and inflammatory responses by binding to glucocorticoid receptors.
• Imidafenacin tablet
• Mirabegron tablet · Urology
  Mirabegron is a beta-3 adrenergic receptor agonist that relaxes the detrusor muscle in the bladder to increase urine storage capacity.
• oxybutynin immediate release · Urology
  Oxybutynin is an anticholinergic that blocks muscarinic receptors in the bladder, leading to relaxation of the detrusor muscle and increased bladder capacity.
• polyvalent pneumococcal vaccine · Immunology / Infectious Disease
  A polyvalent pneumococcal vaccine stimulates the immune system to produce antibodies against multiple serotypes of Streptococcus pneumoniae bacteria.
• Simulect · Nephrology
• solifenacin succinate suspension · Urology
  Solifenacin is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder.
• steroids · Other
• Tacrolimus Ointment 0.03% · Dermatology/Immunology
  Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation and cytokine production to reduce skin inflammation.
• Tacrolimus (Prograf®) · Immunology
  Tacrolimus inhibits calcineurin phosphatase, blocking T-cell activation and proliferation to suppress immune responses.
• Tamsulosin OCAS
• Zolpidem IR · Neurology / Sleep Medicine
  Zolpidem binds to GABA-A receptors in the brain to enhance inhibitory neurotransmission and promote sleep onset.
• Zolpidem MR · Neurology / Sleep Medicine
  Zolpidem MR is a sedative-hypnotic that binds to GABA-A receptors in the brain to promote sleep onset and maintenance.
• Zolpidem (Myslee®) · Neurology / Sleep Medicine
  Zolpidem is a selective benzodiazepine receptor agonist that enhances inhibitory GABA signaling in the central nervous system to promote sleep onset.

Phase 3 pipeline

• ASP1585 · Oncology
  ASP1585 is a selective androgen receptor degrader (SARD) that binds to and promotes degradation of the androgen receptor protein.
• CZP · Immunology
  CZP is a humanized monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling.
• FK199B · Immunology
  FK199B is a selective antagonist of the complement C5a receptor that inhibits complement-mediated inflammation.
• FK463 · Infectious Disease
  FK463 is a fungal cell wall synthesis inhibitor that disrupts β-glucan formation, leading to fungal cell death.
• FK506MR · Immunology
  FK506MR is a modified-release formulation of tacrolimus that suppresses T-cell activation by inhibiting calcineurin phosphatase.
• FK949E · Musculoskeletal / Endocrinology
  FK949E is a selective androgen receptor modulator (SARM) that binds to androgen receptors to promote anabolic effects while minimizing androgenic side effects.
• methylprednisolone and prednisone · Immunology / Rheumatology / General inflammation
  Methylprednisolone and prednisone are corticosteroids that suppress the immune system and reduce inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
• Micafungin (Mycamine) · Infectious Disease
  Micafungin inhibits fungal cell wall synthesis by targeting 1,3-beta-D-glucan synthase, leading to fungal cell death.
• MR4
  MR4 is an investigational compound in development by Astellas Pharma, but its specific mechanism of action is not publicly disclosed.
• OPT-80 · Infectious Disease
  OPT-80 is a macrocyclic antibiotic that inhibits bacterial protein synthesis by binding to the bacterial ribosome.
• overencapsulated caffeine · Central Nervous System
  Overencapsulated caffeine acts as a stimulant by increasing the levels of dopamine and norepinephrine in the brain.
• Placebo to Mirabegron · Urology
  Mirabegron is a beta-3 adrenergic receptor agonist that relaxes the detrusor muscle in the bladder to increase urine storage capacity.
• Placebo to Tolterodine · Urology
  Tolterodine is a muscarinic M3 receptor antagonist that reduces bladder muscle contractions to treat overactive bladder symptoms.
• Prograf-XL · Immunology
  Prograf-XL is an immunosuppressant that inhibits calcineurin.
• RSD1235 · Cardiovascular
  RSD1235 is a potassium channel opener that suppresses atrial fibrillation by prolonging atrial refractoriness and reducing atrial conduction velocity.
• Tamuslosin · Other
• Tamusulosin · Other
• YM060 · Pain
  YM060 is a selective and potent kappa opioid receptor antagonist.
• YM150 · Diabetes
  YM150 is a selective and potent inhibitor of the sodium-glucose cotransporter 2 (SGLT2).
• YM177 · Diabetes
  YM177 is a glucagon-like peptide-1 (GLP-1) receptor agonist.
• YM178 · Diabetes
  YM178 is a selective and potent inhibitor of the sodium-glucose cotransporter 2 (SGLT2).
• YM443 · Psychiatry
  YM443 is a selective and potent inhibitor of the serotonin reuptake transporter.

Phase 2 pipeline

• AC VAX · Infectious Disease
  AC VAX is a vaccine that stimulates the body's immune system to produce antibodies against a specific antigen.
• AGS-1C4D4
• Anti-IL2R AB · Immunology
  Anti-IL2R antibody
• ASP0456 · Oncology
  ASP0456 is a small molecule inhibitor of the CDK9 enzyme.
• ASP1517 · Inflammation
  ASP1517 is a selective and potent inhibitor of the NLRP3 inflammasome.
• ASP3550 · Diabetes
  ASP3550 is a small molecule inhibitor of the sodium-glucose cotransporter 2 (SGLT2).
• ASP4070 · Immunology
  ASP4070 is a selective antagonist of the complement C5a receptor that inhibits complement-mediated inflammation.
• ASP4901
• ASP5094
• ASP8302
• ASP9831 · Immunology
  ASP9831 is a small molecule inhibitor of the PI3K delta subunit.
• atrovastatin · Other
• Betanis · Other
• FK614
• FK788
• Graceptor® · Oncology
  Selective estrogen receptor modulator
• Kiklin capsules
• OSI-461
• Regnite · Other
• steroids, monoclonal anti-IL2R antibody
• Suglat®
• Tacrolimus Inhalation Aerosol
• VCL-CB01
• YM543

Phase 1 pipeline

• AGS-16M8F
• ASK8007
• ASP015K
• ASP0777
• ASP1948
• ASP2246
• ASP3026
• ASP3325
• ASP4396
• ASP5834
• ASP5878
• ESN364
• Lanthanum carbonate hydrate
• Minidril · Other
• mirabegron OCAS
• Mitiglinide calcium hydrate
• OSI-930 and erlotinib
• Solifenacin Succinate Formulation A
• Solifenacin Succinate Formulation B
• TRK-100STP
• YM 155

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Astellas Pharma Inc portfolio CI brief
• Astellas Pharma Inc pipeline updates RSS