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Cyclosporine A eye drops 0.5%

Military Hospital of Tunis · FDA-approved active Small molecule

Cyclosporine A eye drops 0.5% is a Calcineurin inhibitor Small molecule drug developed by Military Hospital of Tunis. It is currently FDA-approved for Dry eye disease (keratoconjunctivitis sicca), Ocular surface inflammation. Also known as: CsA.

Cyclosporine A suppresses T-cell activation and proliferation by inhibiting calcineurin, reducing inflammatory cytokine production in the eye.

Cyclosporine A suppresses T-cell activation and proliferation by inhibiting calcineurin, reducing inflammatory cytokine production in the eye. Used for Dry eye disease (keratoconjunctivitis sicca), Ocular surface inflammation.

At a glance

Generic nameCyclosporine A eye drops 0.5%
Also known asCsA
SponsorMilitary Hospital of Tunis
Drug classCalcineurin inhibitor
TargetCalcineurin (protein phosphatase 2B)
ModalitySmall molecule
Therapeutic areaOphthalmology / Immunology
PhaseFDA-approved

Mechanism of action

Cyclosporine A is a calcineurin inhibitor that blocks the dephosphorylation of nuclear factor of activated T cells (NFAT), preventing T-cell activation and the production of pro-inflammatory cytokines such as IL-2. In the eye, this immunosuppressive action reduces inflammation associated with dry eye disease and other ocular surface inflammatory conditions. The 0.5% ophthalmic formulation delivers the drug topically to the ocular surface.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Cyclosporine A eye drops 0.5%

What is Cyclosporine A eye drops 0.5%?

Cyclosporine A eye drops 0.5% is a Calcineurin inhibitor drug developed by Military Hospital of Tunis, indicated for Dry eye disease (keratoconjunctivitis sicca), Ocular surface inflammation.

How does Cyclosporine A eye drops 0.5% work?

Cyclosporine A suppresses T-cell activation and proliferation by inhibiting calcineurin, reducing inflammatory cytokine production in the eye.

What is Cyclosporine A eye drops 0.5% used for?

Cyclosporine A eye drops 0.5% is indicated for Dry eye disease (keratoconjunctivitis sicca), Ocular surface inflammation.

Who makes Cyclosporine A eye drops 0.5%?

Cyclosporine A eye drops 0.5% is developed and marketed by Military Hospital of Tunis (see full Military Hospital of Tunis pipeline at /company/military-hospital-of-tunis).

Is Cyclosporine A eye drops 0.5% also known as anything else?

Cyclosporine A eye drops 0.5% is also known as CsA.

What drug class is Cyclosporine A eye drops 0.5% in?

Cyclosporine A eye drops 0.5% belongs to the Calcineurin inhibitor class. See all Calcineurin inhibitor drugs at /class/calcineurin-inhibitor.

What development phase is Cyclosporine A eye drops 0.5% in?

Cyclosporine A eye drops 0.5% is FDA-approved (marketed).

What are the side effects of Cyclosporine A eye drops 0.5%?

Common side effects of Cyclosporine A eye drops 0.5% include Ocular irritation / burning sensation, Conjunctival hyperemia, Foreign body sensation, Transient blurred vision.

What does Cyclosporine A eye drops 0.5% target?

Cyclosporine A eye drops 0.5% targets Calcineurin (protein phosphatase 2B) and is a Calcineurin inhibitor.

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