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Control (bupivacaine)
Control (bupivacaine) is a Local anesthetic (amide) Small molecule drug developed by Kasr El Aini Hospital. It is currently FDA-approved for Local anesthesia for infiltration, nerve blocks, and regional anesthesia, Epidural and spinal anesthesia. Also known as: Marcaine.
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.
Bupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local anesthesia for infiltration, nerve blocks, and regional anesthesia, Epidural and spinal anesthesia.
At a glance
| Generic name | Control (bupivacaine) |
|---|---|
| Also known as | Marcaine |
| Sponsor | Kasr El Aini Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby stabilizing the neuronal membrane and preventing depolarization. This action blocks conduction of nerve impulses in sensory, motor, and autonomic nerves depending on the concentration and route of administration. Its longer duration of action compared to other local anesthetics makes it suitable for both infiltration anesthesia and regional nerve blocks.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and regional anesthesia
- Epidural and spinal anesthesia
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures, loss of consciousness)
- Cardiovascular effects (hypotension, bradycardia, arrhythmias)
- Local reactions (pain, erythema at injection site)
- Allergic reactions (rare with amide local anesthetics)
Key clinical trials
- Repeated Bilateral Greater Occipital Nerve Blockade in Chronic Migraine and Chronic Tension-Type Headache (NA)
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block for Analgesia in Arthroscopic Shoulder Surgery (NA)
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy (NA)
- Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy (PHASE4)
- Comparison of Femoral Nerve Block and Combined PENG Plus Femoral Nerve Block in Geriatric Hip Surgery (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Control (bupivacaine) CI brief — competitive landscape report
- Control (bupivacaine) updates RSS · CI watch RSS
- Kasr El Aini Hospital portfolio CI
Frequently asked questions about Control (bupivacaine)
What is Control (bupivacaine)?
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Is Control (bupivacaine) also known as anything else?
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Related
- Drug class: All Local anesthetic (amide) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Kasr El Aini Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local anesthesia for infiltration, nerve blocks, and regional anesthesia
- Indication: Drugs for Epidural and spinal anesthesia
- Also known as: Marcaine
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing