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Combination of prednisone and azathioprine
Combination of prednisone and azathioprine is a Immunosuppressant combination Small molecule drug developed by St. Anne's University Hospital Brno, Czech Republic. It is currently in Phase 3 development for Autoimmune hepatitis, Autoimmune inflammatory conditions requiring immunosuppression.
This combination suppresses the immune system by reducing corticosteroid-mediated inflammation and blocking T-cell proliferation through azathioprine's purine antagonism.
This combination suppresses the immune system by reducing corticosteroid-mediated inflammation and blocking T-cell proliferation through azathioprine's purine antagonism. Used for Autoimmune hepatitis, Autoimmune inflammatory conditions requiring immunosuppression.
At a glance
| Generic name | Combination of prednisone and azathioprine |
|---|---|
| Sponsor | St. Anne's University Hospital Brno, Czech Republic |
| Drug class | Immunosuppressant combination |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | Phase 3 |
Mechanism of action
Prednisone is a corticosteroid that broadly suppresses immune cell activation and inflammatory cytokine production. Azathioprine is a purine analog that inhibits T-cell and B-cell proliferation by interfering with nucleotide synthesis. Together, they provide complementary immunosuppression through different mechanisms, commonly used to manage autoimmune and inflammatory conditions.
Approved indications
- Autoimmune hepatitis
- Autoimmune inflammatory conditions requiring immunosuppression
Common side effects
- Infection
- Bone marrow suppression
- Gastrointestinal disturbance
- Hyperglycemia
- Osteoporosis
Key clinical trials
- A Randomized Study on Pemphigus Treatment With Humanized CD38 Antibody CM313. (PHASE1, PHASE2)
- Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM) (PHASE4)
- Withdraw Drug in Stable IgG4-Related Disease (NA)
- Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis (NA)
- LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis (PHASE2)
- Identifying Young Inflammatory Bowel Disease Patients at Risk for Herpes Zoster
- The Iguratimod Effect on Lupus Nephritis (IGeLU) (PHASE2)
- The Clinical Efficacy of DFPP in Patients With AAGN (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Combination of prednisone and azathioprine CI brief — competitive landscape report
- Combination of prednisone and azathioprine updates RSS · CI watch RSS
- St. Anne's University Hospital Brno, Czech Republic portfolio CI
Frequently asked questions about Combination of prednisone and azathioprine
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Related
- Drug class: All Immunosuppressant combination drugs
- Manufacturer: St. Anne's University Hospital Brno, Czech Republic — full pipeline
- Therapeutic area: All drugs in Immunology
- Indication: Drugs for Autoimmune hepatitis
- Indication: Drugs for Autoimmune inflammatory conditions requiring immunosuppression
- Compare: Combination of prednisone and azathioprine vs similar drugs
- Pricing: Combination of prednisone and azathioprine cost, discount & access