Immunosuppressant combination

This page covers all Immunosuppressant combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Calcineurin (ciclosporin); IMPDH type II (mycophenolate mofetil), Calcineurin (tacrolimus); IMPDH type II (MMF), Calcineurin (tacrolimus); Inosine monophosphate dehydrogenase (mycophenolate mofetil).

Targets

Calcineurin (ciclosporin); IMPDH type II (mycophenolate mofetil) · Calcineurin (tacrolimus); IMPDH type II (MMF) · Calcineurin (tacrolimus); Inosine monophosphate dehydrogenase (mycophenolate mofetil) · IMPDH (mycophenolate); glucocorticoid receptor (dexamethasone)

Marketed (2)

• Ciclosporin and Mycophenolate-mofetil · University of Giessen · Immunology
  This combination suppresses T-cell activation and proliferation through calcineurin inhibition (ciclosporin) and inosine monophosphate dehydrogenase inhibition (mycophenolate mofetil) to prevent organ rejection.
• Tacrolimus/MMF · University of Miami · Immunology / Transplantation
  Tacrolimus and mycophenolate mofetil (MMF) together suppress T-cell and B-cell activation to prevent organ rejection after transplantation.

Phase 3 pipeline (3)

• tacrolimus + mycophenolate mofetil · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan · Immunology / Transplantation
  This combination suppresses T-cell activation and proliferation through calcineurin inhibition (tacrolimus) and inosine monophosphate dehydrogenase inhibition (mycophenolate mofetil) to prevent organ rejection.
• Combination of prednisone and azathioprine · St. Anne's University Hospital Brno, Czech Republic · Immunology
  This combination suppresses the immune system by reducing corticosteroid-mediated inflammation and blocking T-cell proliferation through azathioprine's purine antagonism.
• MMF and Dexamethasone · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Immunology
  MMF (mycophenolate mofetil) suppresses T and B cell proliferation while dexamethasone provides broad immunosuppression and anti-inflammatory effects.