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CHX disinfection
Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes and inhibits metabolic processes.
Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes and inhibits metabolic processes. Used for Oral disinfection and plaque control, Wound disinfection and antisepsis, Skin antisepsis prior to procedures.
At a glance
| Generic name | CHX disinfection |
|---|---|
| Sponsor | University Hospital, Basel, Switzerland |
| Drug class | Antimicrobial disinfectant |
| Modality | Small molecule |
| Therapeutic area | Infection prevention / Disinfection |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged microbial cell membranes, causing leakage of cellular contents and cell death. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. CHX has been used for decades as a topical disinfectant and oral rinse in clinical settings.
Approved indications
- Oral disinfection and plaque control
- Wound disinfection and antisepsis
- Skin antisepsis prior to procedures
Common side effects
- Tooth staining
- Taste alteration
- Oral irritation
- Allergic contact dermatitis
Key clinical trials
- Antimicrobial Efficacy of Four Different Irrigation Protocols (NA)
- Analyzing the Effect of Disinfection Additives on the Linear Dimensional Stability of Dental Alginate Impressions: A Quasi-Experimental Comparative Study (NA)
- Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal (NA)
- Microbiome Changes After Laser and Chlorhexidine Disinfection in Caries Removal (NA)
- Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth. (NA)
- PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site (PHASE4)
- Number of Necessary Paints of Preoperative Skin Disinfection to Prevent Surgical Site Infections
- Antibacterial Effectiveness of Two Root Canal Irrigants (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- CHX disinfection CI brief — competitive landscape report
- CHX disinfection updates RSS · CI watch RSS
- University Hospital, Basel, Switzerland portfolio CI