NCT03668899 is a NA clinical trial of irrigation in Dental Pulp Necrosis, sponsored by Cairo University.

Who is sponsoring NCT03668899?

NCT03668899 is sponsored by Cairo University.

What drugs are being tested in NCT03668899?

Interventions in NCT03668899: irrigation.

What condition does NCT03668899 study?

NCT03668899 studies Dental Pulp Necrosis.

Is NCT03668899 still recruiting?

NCT03668899 is currently completed. Last updated 29 June 2025.

Are results published for NCT03668899?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-06-29 · How we verify

NCT03668899

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Antimicrobial Efficacy of Four Different Irrigation Protocols

Completed NA Results posted Last updated 29 June 2025

What this trial tests

NA trial testing irrigation in Dental Pulp Necrosis in 60 participants. Completed in 15 August 2020.

Timeline

25 January 2020

Primary endpoint
30 April 2020

15 August 2020

Quick facts

Lead sponsor	Cairo University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	25 January 2020
Primary completion	30 April 2020
Estimated completion	15 August 2020
Sites	1 location across Egypt

Drugs / interventions tested

irrigation — full drug profile →

Conditions studied

Dental Pulp Necrosis — all drugs for Dental Pulp Necrosis →

Sponsor

Cairo University

Who can join

Adults 22 to 45, any sex, with Dental Pulp Necrosis. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Number of Colony Forming Units Per Millilitre Primary · 1 week after culture

activity of the irrigating solution against bacteria in the root canal system, the less the number of colony forming units the better the irrigating solution is

preoperative measurements

Group	Value	95% CI
Chitosan NPs Group	80300000	68900000 – 94100000
Chlorhexidine Group	79900000	69700000 – 91400000
Combination Group	74000000	51200000 – 96000000
Hypochlorite Group	73000000	62700000 – 92400000

postoperative measurements

Group	Value	95% CI
Chitosan NPs Group	77000	52000 – 108000
Chlorhexidine Group	124000	83000 – 161000
Combination Group	88000	41000 – 104000
Hypochlorite Group	89000	51000 – 149000

Numerical Rating Scale Secondary · after 6 hours,12 hours, 24 hours, 48 hours, 72 hours and 7 days postoperatively

pain incidence and intensity after root canal treatment The NRS consists of an 11 points line anchored by two extremes "No pain" and "pain as bad as could be"

preoperative pain

Group	Value	95% CI
Chlorhexidine Group	7
Chitosan NPs Group	8
Combination Group	6
Hypochlorite Group	7
Chlorhexidine Group	8
Chitosan NPs Group	7
Combination Group	9
Hypochlorite Group	8
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0

postoperative pain after 6 hours

Group	Value	95% CI
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	2
Hypochlorite Group	2
Chlorhexidine Group	12
Chitosan NPs Group	10
Combination Group	10
Hypochlorite Group	8
Chlorhexidine Group	3
Chitosan NPs Group	5
Combination Group	3
Hypochlorite Group	5

postoperative pain after 12 hours

Group	Value	95% CI
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	7
Chitosan NPs Group	0
Combination Group	8
Hypochlorite Group	3
Chlorhexidine Group	7
Chitosan NPs Group	12
Combination Group	6
Hypochlorite Group	11
Chlorhexidine Group	1
Chitosan NPs Group	3
Combination Group	1
Hypochlorite Group	1

postoperative pain after 24 hours

Group	Value	95% CI
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	12
Chitosan NPs Group	11
Combination Group	13
Hypochlorite Group	12
Chlorhexidine Group	3
Chitosan NPs Group	4
Combination Group	2
Hypochlorite Group	3
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0

postoperative pain after 48 hours

Group	Value	95% CI
Chlorhexidine Group	7
Chitosan NPs Group	7
Combination Group	10
Hypochlorite Group	11
Chlorhexidine Group	8
Chitosan NPs Group	8
Combination Group	5
Hypochlorite Group	4
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0

postoperative pain after 72 hours

Group	Value	95% CI
Chlorhexidine Group	13
Chitosan NPs Group	10
Combination Group	12
Hypochlorite Group	11
Chlorhexidine Group	2
Chitosan NPs Group	5
Combination Group	3
Hypochlorite Group	4
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0

postoperative pain after 7 days

Group	Value	95% CI
Chlorhexidine Group	13
Chitosan NPs Group	14
Combination Group	12
Hypochlorite Group	13
Chlorhexidine Group	2
Chitosan NPs Group	0
Combination Group	3
Hypochlorite Group	2
Chlorhexidine Group	0
Chitosan NPs Group	1
Combination Group	0
Hypochlorite Group	0
Chlorhexidine Group	0
Chitosan NPs Group	0
Combination Group	0
Hypochlorite Group	0

Sponsor's own description

proper disinfection of root canal system before obturation is a must for long term success of endodontic treatment, therefore a proper irrigant is mandatory, therefore investigators are studying the antibacterial effects of 4 different irrgating solutions in root canal treatment of patients diagnosed with necrotic pulps in their mandibular posterior teeth. patients will be recruited from outpatient clinic of the endodontic department in cairo university. endodontic treatment will be carried out as usual and samples from the infected root canals will be collected before and after preparation to be cultivated and analyzed at the laboratories of microbiology of faculty of medicine, cairo university

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Dental Pulp Necrosis

Currently open trials in the same condition.

NCT07048028 — Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) · NA · recruiting

Other Cairo University trials

Trials by the same sponsor.

NCT04155528 — Effect of Music Therapy on Postoperative Health Outcomes · NA · not yet recruiting
NCT07363239 — CBCT-Based Safety Distance for Implant Placement Near the Inferior Alveolar Canal · not yet recruiting
NCT07374575 — Egyptian Dental Professionals' Perspectives on the Oral Microbiome and Exosomes · not yet recruiting
NCT07381153 — In-Vitro Cytotoxicity Assessment of INOX (Nanoksa G Plus) Polymer Discs · not yet recruiting
NCT07375394 — 3D-Printed Extraoral Camera for Standardized Dental Photography · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03668899 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Cairo University
Last refreshed: 29 June 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03668899.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing