{"id":"chx-disinfection","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining"},{"rate":null,"effect":"Taste alteration"},{"rate":null,"effect":"Oral irritation"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a cationic biguanide that binds to negatively charged microbial cell membranes, causing leakage of cellular contents and cell death. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. CHX has been used for decades as a topical disinfectant and oral rinse in clinical settings.","oneSentence":"Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes and inhibits metabolic processes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:19.941Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral disinfection and plaque control"},{"name":"Wound disinfection and antisepsis"},{"name":"Skin antisepsis prior to procedures"}]},"trialDetails":[{"nctId":"NCT03668899","phase":"NA","title":"Antimicrobial Efficacy of Four Different Irrigation Protocols","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-01-25","conditions":"Dental Pulp Necrosis","enrollment":60},{"nctId":"NCT06899672","phase":"NA","title":"Analyzing the Effect of Disinfection Additives on the Linear Dimensional Stability of Dental Alginate Impressions: A Quasi-Experimental Comparative Study","status":"NOT_YET_RECRUITING","sponsor":"Altamash Institute of Dental Medicine","startDate":"2025-04-01","conditions":"Dimensional Changes","enrollment":96},{"nctId":"NCT06836882","phase":"NA","title":"Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal","status":"RECRUITING","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2024-05-23","conditions":"Pulp Disease, Dental","enrollment":159},{"nctId":"NCT06765330","phase":"NA","title":"Microbiome Changes After Laser and Chlorhexidine Disinfection in Caries Removal","status":"NOT_YET_RECRUITING","sponsor":"Mersin University","startDate":"2025-05-05","conditions":"Dental Caries","enrollment":78},{"nctId":"NCT05361278","phase":"NA","title":"Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2021-01-15","conditions":"Dental Caries, Infection, Bacterial, Tooth, Deciduous","enrollment":15},{"nctId":"NCT03685604","phase":"PHASE4","title":"PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2018-09-10","conditions":"Surgical Site Infections","enrollment":3321},{"nctId":"NCT03859375","phase":"","title":"Number of Necessary Paints of Preoperative Skin Disinfection to Prevent Surgical Site Infections","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2019-01-29","conditions":"Surgical Site Infection","enrollment":239},{"nctId":"NCT02747082","phase":"PHASE2","title":"Antibacterial Effectiveness of Two Root Canal Irrigants","status":"COMPLETED","sponsor":"University of Oslo","startDate":"2012-01","conditions":"Periapical Periodontitis","enrollment":49}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"CHX disinfection","genericName":"CHX disinfection","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent that disrupts bacterial and fungal cell membranes and inhibits metabolic processes. Used for Oral disinfection and plaque control, Wound disinfection and antisepsis, Skin antisepsis prior to procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}