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Cholecalciferol 1200
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency prevention and treatment, Calcium homeostasis and bone health maintenance.
At a glance
| Generic name | Cholecalciferol 1200 |
|---|---|
| Also known as | vit D |
| Sponsor | Centre of Postgraduate Medical Education |
| Drug class | Vitamin D supplement |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Nutritional/Metabolic |
| Phase | Phase 3 |
Mechanism of action
Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). The active metabolite binds to vitamin D receptors in target tissues, promoting intestinal calcium and phosphate absorption, regulating bone mineralization, and modulating immune cell differentiation and function. At a dose of 1200 IU daily, it is used for vitamin D supplementation and maintenance of adequate serum vitamin D levels.
Approved indications
- Vitamin D deficiency prevention and treatment
- Calcium homeostasis and bone health maintenance
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Constipation
Key clinical trials
- Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity (PHASE2)
- Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood (PHASE1)
- Romosozumab Use to Build Skeletal Integrity (PHASE4)
- Monthly Boluses Versus Daily Doses for Correcting Blood Vitamin D Deficit in Obese Children and Adolescents (PHASE3)
- Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition. (NA)
- Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas
- The Effect of Aerobic Exercise on Bone Turnover Markers in Postmenopausal Patients (NA)
- Calcium+Calcitriol Versus PTH for the Prevention of Hypocalcemia in Thyroidectomy. Randomized Clinical Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cholecalciferol 1200 CI brief — competitive landscape report
- Cholecalciferol 1200 updates RSS · CI watch RSS
- Centre of Postgraduate Medical Education portfolio CI