{"id":"cholecalciferol-1200","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). The active metabolite binds to vitamin D receptors in target tissues, promoting intestinal calcium and phosphate absorption, regulating bone mineralization, and modulating immune cell differentiation and function. At a dose of 1200 IU daily, it is used for vitamin D supplementation and maintenance of adequate serum vitamin D levels.","oneSentence":"Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:46.098Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency prevention and treatment"},{"name":"Calcium homeostasis and bone health maintenance"}]},"trialDetails":[{"nctId":"NCT05933499","phase":"PHASE2","title":"Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-11-05","conditions":"Obesity","enrollment":63},{"nctId":"NCT00856947","phase":"PHASE1","title":"Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood","status":"ACTIVE_NOT_RECRUITING","sponsor":"Copenhagen Studies on Asthma in Childhood","startDate":"2009-03","conditions":"Asthma","enrollment":600},{"nctId":"NCT05058976","phase":"PHASE4","title":"Romosozumab Use to Build Skeletal Integrity","status":"ACTIVE_NOT_RECRUITING","sponsor":"Susan L. 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