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Chlorhexidine 0.06% mouthrinse
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load.
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load. Used for Plaque and gingivitis reduction, Oral antimicrobial rinse for periodontal disease prevention.
At a glance
| Generic name | Chlorhexidine 0.06% mouthrinse |
|---|---|
| Also known as | Corsodaily 0.06% chlorhexidine mouthwash |
| Sponsor | University of Oslo |
| Drug class | Antimicrobial oral rinse |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Oral health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also precipitates bacterial proteins and nucleic acids. At the 0.06% concentration used in mouthrinse formulations, it provides antimicrobial activity against a wide range of gram-positive and gram-negative oral bacteria, helping to reduce plaque formation and gingivitis.
Approved indications
- Plaque and gingivitis reduction
- Oral antimicrobial rinse for periodontal disease prevention
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or burning
- Increased calculus formation
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorhexidine 0.06% mouthrinse CI brief — competitive landscape report
- Chlorhexidine 0.06% mouthrinse updates RSS · CI watch RSS
- University of Oslo portfolio CI