{"id":"chlorhexidine-0-06-mouthrinse","safety":{"commonSideEffects":[{"rate":"5-30","effect":"Tooth staining (brown discoloration)"},{"rate":"5-15","effect":"Taste alteration"},{"rate":"1-5","effect":"Oral irritation or burning"},{"rate":"null","effect":"Increased calculus formation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and cell death. It also precipitates bacterial proteins and nucleic acids. At the 0.06% concentration used in mouthrinse formulations, it provides antimicrobial activity against a wide range of gram-positive and gram-negative oral bacteria, helping to reduce plaque formation and gingivitis.","oneSentence":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:25.708Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Plaque and gingivitis reduction"},{"name":"Oral antimicrobial rinse for periodontal disease prevention"}]},"trialDetails":[{"nctId":"NCT02911766","phase":"PHASE4","title":"Efficacy of Different Chlorhexidine Concentrations","status":"UNKNOWN","sponsor":"University of Oslo","startDate":"2016-11","conditions":"Dental Plaque, Gingivitis","enrollment":59}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Corsodaily 0.06% chlorhexidine mouthwash"],"phase":"marketed","status":"active","brandName":"Chlorhexidine 0.06% mouthrinse","genericName":"Chlorhexidine 0.06% mouthrinse","companyName":"University of Oslo","companyId":"university-of-oslo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, reducing oral microbial load. Used for Plaque and gingivitis reduction, Oral antimicrobial rinse for periodontal disease prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}