Last reviewed 2026-06-02 · How we verify

Cefazolin 2 GM Injection

Cefazolin 2 GM Injection is a First-generation cephalosporin Small molecule drug developed by Abdul El-Rabbany. It is currently FDA-approved for Bacterial infections caused by susceptible organisms (respiratory tract, skin and soft tissue, urinary tract, biliary tract, bone and joint infections), Surgical prophylaxis, Endocarditis prophylaxis in susceptible patients. Also known as: Single Dose IV Cefazolin.

Cefazolin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking cross-linking of peptidoglycan.

Cefazolin 2 GM Injection is used to prevent infections in certain medical procedures, such as medical thoracoscopy, and has been studied for its efficacy and safety in treating conditions like pleural effusion, pleurisy, and empyema. It is administered as a single dose injection, and its mechanism of action involves inhibiting bacterial cell wall synthesis, as indicated by its classification in ChEMBL.

At a glance

Mechanism of action

Cefazolin is a first-generation cephalosporin that acts as a bactericidal agent. It penetrates the bacterial cell wall and binds to penicillin-binding proteins, preventing the cross-linking of peptidoglycan strands essential for cell wall integrity. This leads to cell wall rupture and bacterial death, making it effective against a broad spectrum of gram-positive and some gram-negative bacteria.

Approved indications

• Bacterial infections caused by susceptible organisms (respiratory tract, skin and soft tissue, urinary tract, biliary tract, bone and joint infections)
• Surgical prophylaxis
• Endocarditis prophylaxis in susceptible patients

Common side effects

• Hypersensitivity reactions (rash, urticaria)
• Phlebitis at injection site
• Diarrhea
• Nausea and vomiting
• Anaphylaxis

Key clinical trials

• Antibiotics for Prevention of Infection Following Orthognathic Surgery (PHASE4)
• Comparing of Cefazolin Plus Azithromycin Versus Cefazolin in Prevention of Febrile Morbidity After Emergency Cesarean Delivery (NA)
• Antibiotics During Intrauterine Balloon Tamponade Placement (PHASE4)
• Pediatric Cefazolin PK Study (PHASE1)
• Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Cefazolin 2 GM Injection CI brief — competitive landscape report
• Cefazolin 2 GM Injection updates RSS · CI watch RSS
• Abdul El-Rabbany portfolio CI

Frequently asked questions about Cefazolin 2 GM Injection

Related

• Drug class: All First-generation cephalosporin drugs
• Target: All drugs targeting Penicillin-binding proteins (PBPs)
• Manufacturer: Abdul El-Rabbany — full pipeline
• Therapeutic area: All drugs in Infectious Disease
• Indication: Drugs for Bacterial infections caused by susceptible organisms (respiratory tract, skin and soft tissue, urinary tract, biliary tract, bone and joint infections)
• Indication: Drugs for Surgical prophylaxis
• Indication: Drugs for Endocarditis prophylaxis in susceptible patients
• Also known as: Single Dose IV Cefazolin

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing