{"id":"cefazolin-2-gm-injection","safety":{"commonSideEffects":[{"rate":"1-3","effect":"Hypersensitivity reactions (rash, urticaria)"},{"rate":"1-2","effect":"Phlebitis at injection site"},{"rate":"1-2","effect":"Diarrhea"},{"rate":"0.5-1","effect":"Nausea and vomiting"},{"rate":"0.01-0.1","effect":"Anaphylaxis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cefazolin is a first-generation cephalosporin that acts as a bactericidal agent. It penetrates the bacterial cell wall and binds to penicillin-binding proteins, preventing the cross-linking of peptidoglycan strands essential for cell wall integrity. This leads to cell wall rupture and bacterial death, making it effective against a broad spectrum of gram-positive and some gram-negative bacteria.","oneSentence":"Cefazolin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins and blocking cross-linking of peptidoglycan.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:43:14.707Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial infections caused by susceptible organisms (respiratory tract, skin and soft tissue, urinary tract, biliary tract, bone and joint infections)"},{"name":"Surgical prophylaxis"},{"name":"Endocarditis prophylaxis in susceptible patients"}]},"trialDetails":[{"nctId":"NCT05852158","phase":"PHASE4","title":"Antibiotics for Prevention of Infection Following Orthognathic Surgery","status":"RECRUITING","sponsor":"Abdul El-Rabbany","startDate":"2024-01-09","conditions":"Orthognathic Surgical Site Infection","enrollment":400},{"nctId":"NCT05647993","phase":"NA","title":"Comparing of Cefazolin Plus Azithromycin Versus Cefazolin in Prevention of Febrile Morbidity After Emergency Cesarean Delivery","status":"COMPLETED","sponsor":"Department of Medical Services Ministry of Public Health of Thailand","startDate":"2022-12-14","conditions":"Febrile Morbidity After Emergency Cesarean Section","enrollment":172},{"nctId":"NCT03478163","phase":"PHASE4","title":"Antibiotics During Intrauterine Balloon Tamponade Placement","status":"TERMINATED","sponsor":"Cedars-Sinai Medical Center","startDate":"2018-03-08","conditions":"Obstetric Complication, Postpartum Hemorrhage, Postpartum Endometritis","enrollment":11},{"nctId":"NCT01904357","phase":"PHASE1","title":"Pediatric Cefazolin PK Study","status":"COMPLETED","sponsor":"B. Braun Medical Inc.","startDate":"2013-03","conditions":"Infections","enrollment":12},{"nctId":"NCT02446782","phase":"PHASE4","title":"Efficacy and Safety of Prophylactic Use of an Antibiotic for Medical Thoracoscopy","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2015-01","conditions":"Pleural Effusion, Pleurisy, Empyema","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Single Dose IV Cefazolin"],"phase":"marketed","status":"active","brandName":"Cefazolin 2 GM Injection","genericName":"Cefazolin 2 GM Injection","companyName":"Abdul El-Rabbany","companyId":"abdul-el-rabbany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cefazolin 2 GM Injection is used to prevent infections in certain medical procedures, such as medical thoracoscopy, and has been studied for its efficacy and safety in treating conditions like pleural effusion, pleurisy, and empyema. It is administered as a single dose injection, and its mechanism of action involves inhibiting bacterial cell wall synthesis, as indicated by its classification in ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}