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Carica Papaya Leaf Extract
Carica papaya leaf extract stimulates platelet production and enhances immune function through bioactive compounds including alkaloids, phenolics, and enzymes.
Carica papaya leaf extract stimulates platelet production and enhances immune function through bioactive compounds including alkaloids, phenolics, and enzymes. Used for Thrombocytopenia (low platelet count), Dengue fever with thrombocytopenia.
At a glance
| Generic name | Carica Papaya Leaf Extract |
|---|---|
| Sponsor | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh |
| Drug class | Herbal extract |
| Modality | Small molecule |
| Therapeutic area | Hematology |
| Phase | Phase 3 |
Mechanism of action
The extract contains multiple phytochemical constituents that may promote megakaryopoiesis and platelet generation, while also modulating immune responses. It has been traditionally used and investigated for its potential to increase platelet counts in thrombocytopenic conditions. The mechanism likely involves both direct hematopoietic stimulation and immunomodulatory pathways.
Approved indications
- Thrombocytopenia (low platelet count)
- Dengue fever with thrombocytopenia
Common side effects
- Gastrointestinal upset
- Allergic reactions
Key clinical trials
- To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia (PHASE2)
- Effects of Carica Papaya Leaf Extract (CPLE) in the Outcome of Hospitalized Dengue Patients (PHASE1, PHASE2)
- A Study to Evaluate Efficacy of Dietary Ingredient in Vitality and Metabolic Factors in Healthy Individuals (NA)
- Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial (PHASE3)
- Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation (NA)
- Thrombocytopenia Induced by Chemotherapy (NA)
- Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure (NA)
- The Efficacy and Safety of Topical Papaya (Carica Papaya) Leaf Extract 1% Ointment Versus Mupirocin 2% Ointment in the Treatment of Limited Impetigo: a Randomized, Double-blind, Controlled Clinical Trial (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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