{"id":"carica-papaya-leaf-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL2074677","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains multiple phytochemical constituents that may promote megakaryopoiesis and platelet generation, while also modulating immune responses. It has been traditionally used and investigated for its potential to increase platelet counts in thrombocytopenic conditions. The mechanism likely involves both direct hematopoietic stimulation and immunomodulatory pathways.","oneSentence":"Carica papaya leaf extract stimulates platelet production and enhances immune function through bioactive compounds including alkaloids, phenolics, and enzymes.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:04:58.257Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombocytopenia (low platelet count)"},{"name":"Dengue fever with thrombocytopenia"}]},"trialDetails":[{"nctId":"NCT07172100","phase":"PHASE2","title":"To Assess the Efficacy of Carica Papaya Leaf Extract in Improving Platelet Counts Among Pediatric Patients With Dengue-associated Thrombocytopenia","status":"ENROLLING_BY_INVITATION","sponsor":"Ziauddin Hospital","startDate":"2025-10-01","conditions":"Dengue Fever, Papaya Leaf Extract, Pediatric Patients","enrollment":100},{"nctId":"NCT06945679","phase":"PHASE1, PHASE2","title":"Effects of Carica Papaya Leaf Extract (CPLE) in the Outcome of Hospitalized Dengue Patients","status":"COMPLETED","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2024-06-01","conditions":"Dengue Fever","enrollment":184},{"nctId":"NCT06188949","phase":"NA","title":"A Study to Evaluate Efficacy of Dietary Ingredient in Vitality and Metabolic Factors in Healthy Individuals","status":"COMPLETED","sponsor":"Vedic Lifesciences Pvt. Ltd.","startDate":"2024-02-02","conditions":"Aging","enrollment":35},{"nctId":"NCT06121934","phase":"PHASE3","title":"Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial","status":"COMPLETED","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2023-10-01","conditions":"Dengue","enrollment":250},{"nctId":"NCT05360134","phase":"NA","title":"Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation","status":"UNKNOWN","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2021-01-01","conditions":"Thrombocytopenia","enrollment":30},{"nctId":"NCT03567798","phase":"NA","title":"Thrombocytopenia Induced by Chemotherapy","status":"COMPLETED","sponsor":"Socrates School Of Health","startDate":"2017-07-18","conditions":"Thrombocytopenia","enrollment":60},{"nctId":"NCT03486145","phase":"NA","title":"Effect of Nitrate-rich Fruit and Vegetable Supplement on Blood Pressure","status":"COMPLETED","sponsor":"Arizona State University","startDate":"2015-11-16","conditions":"High Blood Pressure, Flow Mediated Dilation","enrollment":57},{"nctId":"NCT01943136","phase":"PHASE1","title":"The Efficacy and Safety of Topical Papaya (Carica Papaya) Leaf Extract 1% Ointment Versus Mupirocin 2% Ointment in the Treatment of Limited Impetigo: a Randomized, Double-blind, Controlled Clinical Trial","status":"UNKNOWN","sponsor":"Philippine Dermatological Society","startDate":"2013-08","conditions":"Impetigo","enrollment":128}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":43,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Carica Papaya Leaf Extract","genericName":"Carica Papaya Leaf Extract","companyName":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","companyId":"bangabandhu-sheikh-mujib-medical-university-dhaka-bangladesh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carica papaya leaf extract stimulates platelet production and enhances immune function through bioactive compounds including alkaloids, phenolics, and enzymes. Used for Thrombocytopenia (low platelet count), Dengue fever with thrombocytopenia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}