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Calcium Hydroxide (Ca(OH)2)
Calcium Hydroxide (Ca(OH)2) is a Inorganic alkaline compound Small molecule drug developed by Umm Al-Qura University. It is currently FDA-approved for Intracanal medicament in endodontic treatment, Pulp capping in restorative dentistry, Root canal disinfection and treatment. Also known as: Ca(OH)2.
Calcium hydroxide is a strong alkaline compound that neutralizes acids, disinfects tissues, and promotes mineralization and healing in dental and endodontic applications.
Calcium hydroxide is a strong alkaline compound that neutralizes acids, disinfects tissues, and promotes mineralization and healing in dental and endodontic applications. Used for Intracanal medicament in endodontic treatment, Pulp capping in restorative dentistry, Root canal disinfection and treatment.
At a glance
| Generic name | Calcium Hydroxide (Ca(OH)2) |
|---|---|
| Also known as | Ca(OH)2 |
| Sponsor | Umm Al-Qura University |
| Drug class | Inorganic alkaline compound |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Endodontics |
| Phase | FDA-approved |
Mechanism of action
Calcium hydroxide dissociates to release hydroxyl ions that create an alkaline environment, which has antimicrobial properties against endodontic pathogens and promotes hard tissue formation. It is commonly used in dentistry as an intracanal medicament, pulp capping agent, and root canal sealer component due to its biocompatibility and ability to stimulate dentin bridge formation and periapical healing.
Approved indications
- Intracanal medicament in endodontic treatment
- Pulp capping in restorative dentistry
- Root canal disinfection and treatment
Common side effects
- Tissue irritation if extruded beyond apex
- Allergic reaction (rare)
- Discoloration of tooth structure
Key clinical trials
- Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp. (NA)
- Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment (NA)
- Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth (PHASE4)
- Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain (PHASE4)
- Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids (NA)
- Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste (NA)
- Tobradex as Intracanal Medicament (NA)
- Pulpotomy With CEM vs Pulpectomy With Ca(OH)2/Iodoform in Primary Molars (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Calcium Hydroxide (Ca(OH)2) CI brief — competitive landscape report
- Calcium Hydroxide (Ca(OH)2) updates RSS · CI watch RSS
- Umm Al-Qura University portfolio CI
Frequently asked questions about Calcium Hydroxide (Ca(OH)2)
What is Calcium Hydroxide (Ca(OH)2)?
How does Calcium Hydroxide (Ca(OH)2) work?
What is Calcium Hydroxide (Ca(OH)2) used for?
Who makes Calcium Hydroxide (Ca(OH)2)?
Is Calcium Hydroxide (Ca(OH)2) also known as anything else?
What drug class is Calcium Hydroxide (Ca(OH)2) in?
What development phase is Calcium Hydroxide (Ca(OH)2) in?
What are the side effects of Calcium Hydroxide (Ca(OH)2)?
Related
- Drug class: All Inorganic alkaline compound drugs
- Manufacturer: Umm Al-Qura University — full pipeline
- Therapeutic area: All drugs in Dentistry / Endodontics
- Indication: Drugs for Intracanal medicament in endodontic treatment
- Indication: Drugs for Pulp capping in restorative dentistry
- Indication: Drugs for Root canal disinfection and treatment
- Also known as: Ca(OH)2
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing