{"id":"calcium-hydroxide-ca-oh-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Tissue irritation if extruded beyond apex"},{"rate":null,"effect":"Allergic reaction (rare)"},{"rate":null,"effect":"Discoloration of tooth structure"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Calcium hydroxide dissociates to release hydroxyl ions that create an alkaline environment, which has antimicrobial properties against endodontic pathogens and promotes hard tissue formation. It is commonly used in dentistry as an intracanal medicament, pulp capping agent, and root canal sealer component due to its biocompatibility and ability to stimulate dentin bridge formation and periapical healing.","oneSentence":"Calcium hydroxide is a strong alkaline compound that neutralizes acids, disinfects tissues, and promotes mineralization and healing in dental and endodontic applications.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:37.909Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intracanal medicament in endodontic treatment"},{"name":"Pulp capping in restorative dentistry"},{"name":"Root canal disinfection and treatment"}]},"trialDetails":[{"nctId":"NCT07495605","phase":"NA","title":"Effect of 1% Melatonin Gel Versus Calcium Hydroxide as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp.","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-03-22","conditions":"Intensity of Postoperative Pain, Bacterial Load Reduction and Periapical MMP-9 Levels in Patients With Necrotic Pulp","enrollment":50},{"nctId":"NCT07239739","phase":"NA","title":"Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment","status":"NOT_YET_RECRUITING","sponsor":"Faiz ur rahman","startDate":"2026-06-15","conditions":"Periapical Lesion, Periapical Periodontitis","enrollment":62},{"nctId":"NCT06683833","phase":"PHASE4","title":"Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth","status":"RECRUITING","sponsor":"Cairo University","startDate":"2025-09-03","conditions":"Deep Caries, Indirect Pulp Capping, Mineral Trioxide Aggregate (MTA)","enrollment":35},{"nctId":"NCT07388888","phase":"PHASE4","title":"Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-02","conditions":"Pulp Necrosis","enrollment":52},{"nctId":"NCT07371416","phase":"NA","title":"Regenerative Root Canal Treatment of Immature Teeth Using Omega-3 Fatty Acids","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2025-10-01","conditions":"Immature Permanent Teeth With Open Apex, Pulp Necrosis","enrollment":20},{"nctId":"NCT07340944","phase":"NA","title":"Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste","status":"COMPLETED","sponsor":"Ataturk University","startDate":"2022-09-10","conditions":"Chronic Apical Periodontitis","enrollment":45},{"nctId":"NCT07332936","phase":"NA","title":"Tobradex as Intracanal Medicament","status":"COMPLETED","sponsor":"Umm Al-Qura University","startDate":"2023-07-01","conditions":"Symptomatic Irreversible Pulpitis, Postoperative Endodontic Pain Following Emergency Root Canal Treatment","enrollment":43},{"nctId":"NCT07265063","phase":"NA","title":"Pulpotomy With CEM vs Pulpectomy With Ca(OH)2/Iodoform in Primary Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-12-01","conditions":"Carious Primary Molars","enrollment":50},{"nctId":"NCT07194837","phase":"NA","title":"The Efficiency of 810 nm Diode Laser on Periapical Healing After Root Canal Retreatment","status":"RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-09-19","conditions":"This Study Will be Performed to Evaluate the Efficiency of 810 nm Diode Laser Disinfection on Periapical Healing in Root Canal Retreatment Cases","enrollment":40},{"nctId":"NCT06291623","phase":"PHASE1","title":"Molecular Analysis of Intracanal Microbes After Chemomechanical Procedure and Root Canal Medication: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2022-05-03","conditions":"Bacterial Viability of Necrotic Pulp With Asymptomatic Apical Periodontitis","enrollment":20},{"nctId":"NCT06807320","phase":"PHASE4","title":"COMPARISON of MINERAL TRIOXIDE AGGREGATE and CALCIUM HYDROXIDE AS INDIRECT PULP CAPPING AGENTS in PRIMARY MOLARS","status":"COMPLETED","sponsor":"Shaheed Zulfiqar Ali Bhutto Medical University","startDate":"2022-01-01","conditions":"Indirect Pulp Cap","enrollment":40},{"nctId":"NCT04978545","phase":"NA","title":"The Effect of Ca(OH)2 in Apical Periodontitis","status":"COMPLETED","sponsor":"Seyda Ersahan, DDS, PhD","startDate":"2019-01-01","conditions":"Periapical Periodontitis, Polymerase Chain Reaction, Intracanal Medicament","enrollment":16},{"nctId":"NCT06466538","phase":"PHASE2, PHASE3","title":"Investigate\"Clinically\" the Effectiveness of Boswellia Based Intracanal Medication Compared to Calcium Hydroxide Ca(OH)2 and Ledermix on the Levels of Bacteria and Inflammatory Cytokines in Root Canals and Periradicular Tissues of Teeth With Apical Periodontitis","status":"RECRUITING","sponsor":"Mansoura University","startDate":"2022-06-01","conditions":"Microbial Colonization","enrollment":36},{"nctId":"NCT02492841","phase":"PHASE2, PHASE3","title":"Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth","status":"COMPLETED","sponsor":"Universidad de los Andes, Chile","startDate":"2014-04","conditions":"Caries, Dental Pulp Exposure","enrollment":169},{"nctId":"NCT06253247","phase":"NA","title":"Effect of NanoChitosan Impregnated Calcium Hydroxide as an Intracanal Medication on Postoperative Pain Intensity and Bacterial Load Reduction","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2024-04","conditions":"Intervention","enrollment":45},{"nctId":"NCT05581706","phase":"NA","title":"Regenerative Endodontics Using Different Intracanal Medicaments on Radiographic Outcomes and Periapical MMP-8 Levels","status":"COMPLETED","sponsor":"Ege University","startDate":"2017-09-01","conditions":"Regenerative Endodontics","enrollment":23},{"nctId":"NCT05666089","phase":"EARLY_PHASE1","title":"Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-02-01","conditions":"Intracanal Medication, N-acetylcystine, Calcium Hydroxide","enrollment":30},{"nctId":"NCT05347160","phase":"NA","title":"Evaluation Of Different Pulpotomy Agents Used For Treatment Of Immature Molars","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2021-08-01","conditions":"Infected Pulp, Root Canal Treatment","enrollment":17},{"nctId":"NCT04000854","phase":"NA","title":"Regenerative Treatment of Traumatized Immature Permanent Incisors With Pulp Necrosis","status":"UNKNOWN","sponsor":"Karolinska Institutet","startDate":"2019-02-19","conditions":"Regenerative Endodontics in Traumatized Immature Teeth","enrollment":180},{"nctId":"NCT05052814","phase":"NA","title":"The Effect of Root-canal Medicaments on Post-operative Pain in Re-treatment Cases","status":"COMPLETED","sponsor":"Aydin Adnan Menderes University","startDate":"2019-03-23","conditions":"Endodontically Treated Teeth","enrollment":120},{"nctId":"NCT04265833","phase":"NA","title":"Evaluation of Three Different Pulp Capping Materials in Indirect Pulp Treatment of Primary Teeth","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2015-02-08","conditions":"Deep Caries","enrollment":109},{"nctId":"NCT04213716","phase":"PHASE2","title":"Comparison of the Efficacy of Calcium Hydroxide With Silver Nanoparticle and Conventional Calcium Hydroxide Intra Canal Medications on Post-Operative Pain in Symptomatic Root Canal Treatment Failure Cases:","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-06-15","conditions":"Retreatment, Root Canal Retreatment, Nonsurgical Retreatment","enrollment":120},{"nctId":"NCT03403985","phase":"NA","title":"Long-term Evaluation of Direct Pulp Capping","status":"UNKNOWN","sponsor":"Jordan University of Science and Technology","startDate":"2017-06-01","conditions":"Dental Pulp Capping, Dental Caries Extending to Pulp","enrollment":80},{"nctId":"NCT03425123","phase":"NA","title":"Endodontic Regenerative Procedure for Immature Non-vital Teeth","status":"WITHDRAWN","sponsor":"Boston University","startDate":"2019-06","conditions":"Tooth, Nonvital","enrollment":""},{"nctId":"NCT03855501","phase":"NA","title":"Apexification Treatment With MTA(Mineral Trioxide Aggregate) and Ca(OH)2","status":"COMPLETED","sponsor":"Ege University","startDate":"2015-01","conditions":"Immature Teeth","enrollment":90},{"nctId":"NCT03849222","phase":"PHASE2, PHASE3","title":"Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2013-08-20","conditions":"Pulp Necrosis, Apexification","enrollment":32},{"nctId":"NCT03631277","phase":"NA","title":"Indirect Pulp Treatment of Young Permanent Molars Using Photo-Activated Oral Disinfection Versus Calcium Hydroxide","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-01","conditions":"Deep Caries","enrollment":32},{"nctId":"NCT03488316","phase":"NA","title":"Influence of Temporary Filling Material Composition on the Success Rate of Endodontic Treatments","status":"UNKNOWN","sponsor":"PAULO VINICIUS SOARES","startDate":"2018-05-01","conditions":"MTA, Calcium Hydroxide, Endodontic Treatment","enrollment":20},{"nctId":"NCT03284697","phase":"NA","title":"Direct Pulp Capping With MTA and Calcium Hydroxide.","status":"COMPLETED","sponsor":"Postgraduate Institute of Dental Sciences Rohtak","startDate":"2016-10-14","conditions":"Reversible Pulpitis","enrollment":64},{"nctId":"NCT03009006","phase":"NA","title":"Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2017-01-03","conditions":"Necrotic Pulp","enrollment":45},{"nctId":"NCT02824601","phase":"PHASE2","title":"Photodynamic Therapy in Endodontic Treatment","status":"COMPLETED","sponsor":"Universidade Estadual Paulista Júlio de Mesquita Filho","startDate":"2015-02","conditions":"Endodontic Disease","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ca(OH)2"],"phase":"marketed","status":"active","brandName":"Calcium Hydroxide (Ca(OH)2)","genericName":"Calcium Hydroxide (Ca(OH)2)","companyName":"Umm Al-Qura University","companyId":"umm-al-qura-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calcium hydroxide is a strong alkaline compound that neutralizes acids, disinfects tissues, and promotes mineralization and healing in dental and endodontic applications. Used for Intracanal medicament in endodontic treatment, Pulp capping in restorative dentistry, Root canal disinfection and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}