NCT07371416 (Regeneration) is a NA clinical trial of Omega -3 fatty acids in Immature Permanent Teeth With Open Apex, sponsored by Mansoura University.

Who is sponsoring NCT07371416?

NCT07371416 is sponsored by Mansoura University.

What drugs are being tested in NCT07371416?

Interventions in NCT07371416: Omega -3 fatty acids, Calcium Hydroxide (Ca(OH)2).

What condition does NCT07371416 study?

NCT07371416 studies Immature Permanent Teeth With Open Apex, Pulp Necrosis.

Is NCT07371416 still recruiting?

NCT07371416 is currently active, enrolled. Last updated 19 January 2026.

Last reviewed 2026-01-19 · How we verify

NCT07371416: Regeneration

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Outcomes of Immature Teeth Treated With Regenerative Endodontic Procedures Using Intracanal Delivery of Omega-3 Fatty Acids

Active, enrolled NA Last updated 19 January 2026

What this trial tests

NA trial testing Omega -3 fatty acids in Immature Permanent Teeth With Open Apex in 20 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 October 2025

Primary endpoint
1 December 2026

1 January 2027

Quick facts

Lead sponsor	Mansoura University
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	20
Start date	1 October 2025
Primary completion	1 December 2026
Estimated completion	1 January 2027
Sites	1 location across Egypt

Drugs / interventions tested

Omega -3 fatty acids
Calcium Hydroxide (Ca(OH)2) — full drug profile →

Conditions studied

Immature Permanent Teeth With Open Apex — all drugs for Immature Permanent Teeth With Open Apex →
Pulp Necrosis — all drugs for Pulp Necrosis →

Sponsor

Mansoura University

Who can join

Adults 6 to 28, any sex, with Immature Permanent Teeth With Open Apex or Pulp Necrosis. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Increase in Root Length
Time frame: 12 months
Radiographic increase in root length (Millimeters (mm))
Increase in Dentinal Wall Thickness
Time frame: 12 months
Radiographic increase in dentinal wall thickness measured using digital image analysis ( Millimeters (mm) )
Periapical Bone Formation
Time frame: 12 months
Radiographic evidence of periapical bone formation

Sponsor's own description

This clinical study will be conducted to evaluate the effect of using intracanal Omega-3 Fatty acids during revascularization of necrotic immature teeth compared to the traditional induced bleeding technique.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of Omega -3 fatty acids

Trials testing the same drug.

NCT07036952 — Effect of Omega-3 Supplementation as Add on Therapy on Metabolic Syndrome in Women With Polycystic Ovary Syndrome. · NA · enrolling by invitation

Other Mansoura University trials

Trials by the same sponsor.

NCT05785377 — Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia · NA · not yet recruiting
NCT07509567 — Conventional Palatal Crib Versus Bonded Spurs for Anterior Open Bite Treatment · NA · not yet recruiting
NCT07393178 — Efficacy & Safety of High Power vs. Low Power Holmium Laser in Mini-PCNL for Large Renal Stones · NA · not yet recruiting
NCT07436182 — Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. · Phase 4 · not yet recruiting
NCT07534943 — Effectiveness of Oleanolic Acid as Intracanal Medicament on Infectious/Inflammatory Contents in Teeth With Apical Period · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07371416 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mansoura University
Last refreshed: 19 January 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07371416.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing