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Bupivacaine HCl infiltration
Bupivacaine HCl infiltration is a Local anesthetic Small molecule drug developed by Innocoll. It is currently in Phase 3 development for Local infiltration anesthesia for surgical procedures. Also known as: Marcaine, Marcaine; Local Infiltration.
Bupivacaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local infiltration anesthesia for surgical procedures.
At a glance
| Generic name | Bupivacaine HCl infiltration |
|---|---|
| Also known as | Marcaine, Marcaine; Local Infiltration |
| Sponsor | Innocoll |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | Phase 3 |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the infiltrated tissue. The HCl salt form enhances solubility and stability for clinical administration.
Approved indications
- Local infiltration anesthesia for surgical procedures
Common side effects
- Injection site reactions
- Systemic toxicity (CNS effects)
- Cardiovascular effects
- Allergic reactions
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery (NA)
- Mid-transverse Process Combined With Erector Spinae Block Versus Paravertebral Plane Block (NA)
- Postoperative Analgesia and Ventilation After Cardiac Surgery
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- Bupivacaine for Postoperative Pain After Laparoscopic Hysterectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine HCl infiltration CI brief — competitive landscape report
- Bupivacaine HCl infiltration updates RSS · CI watch RSS
- Innocoll portfolio CI
Frequently asked questions about Bupivacaine HCl infiltration
What is Bupivacaine HCl infiltration?
How does Bupivacaine HCl infiltration work?
What is Bupivacaine HCl infiltration used for?
Who makes Bupivacaine HCl infiltration?
Is Bupivacaine HCl infiltration also known as anything else?
What drug class is Bupivacaine HCl infiltration in?
What development phase is Bupivacaine HCl infiltration in?
What are the side effects of Bupivacaine HCl infiltration?
What does Bupivacaine HCl infiltration target?
Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Innocoll — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Local infiltration anesthesia for surgical procedures
- Also known as: Marcaine, Marcaine; Local Infiltration
- Compare: Bupivacaine HCl infiltration vs similar drugs
- Pricing: Bupivacaine HCl infiltration cost, discount & access