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Bupivacaine alone
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia, Regional anesthesia for surgical and dental procedures, Pain management in perioperative settings.
At a glance
| Generic name | Bupivacaine alone |
|---|---|
| Also known as | vivacaine |
| Sponsor | The University of Texas Health Science Center, Houston |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential propagation. This results in local anesthesia and loss of sensation in the area where it is administered. It is a long-acting amide local anesthetic with a relatively slow onset but prolonged duration of action.
Approved indications
- Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia
- Regional anesthesia for surgical and dental procedures
- Pain management in perioperative settings
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Tinnitus
- Systemic toxicity (CNS and cardiac effects at high doses)
- Allergic reactions
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Bilateral Cervical Plexus Block for Postoperative Pain After Thyroidectomy (NA)
- Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy (PHASE4)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy (PHASE1, PHASE2)
- Comparison of the Analgesic Efficacy of Chest Wall Blocks in Coronary Artery Bypass Surgery (NA)
- Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty (NA)
- Intercostal Nerve Cryoablation Versus Epidural Analgesia for Nuss Repair of Pectus Excavatum (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine alone CI brief — competitive landscape report
- Bupivacaine alone updates RSS · CI watch RSS
- The University of Texas Health Science Center, Houston portfolio CI