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Botulinum Toxin commonly known as BOTOX®

NYU Langone Health · Phase 3 active Small molecule

Botulinum Toxin commonly known as BOTOX® is a Neurotoxin; acetylcholine release inhibitor Small molecule drug developed by NYU Langone Health. It is currently in Phase 3 development for Cervical dystonia, Blepharospasm, Strabismus. Also known as: BOTOX®, Saline.

Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.

Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.

At a glance

Generic nameBotulinum Toxin commonly known as BOTOX®
Also known asBOTOX®, Saline
SponsorNYU Langone Health
Drug classNeurotoxin; acetylcholine release inhibitor
TargetSNARE complex proteins (SNAP-25, VAMP, syntaxin)
ModalitySmall molecule
Therapeutic areaNeurology; Aesthetics; Pain Management
PhasePhase 3

Mechanism of action

Botulinum toxin is a neurotoxin that irreversibly cleaves proteins required for acetylcholine vesicle fusion and release at the presynaptic terminal. This prevents neuromuscular transmission, resulting in flaccid paralysis of the targeted muscle. The effect is temporary, lasting 3-4 months, as the body gradually regenerates the cleaved proteins and forms new neuromuscular junctions.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Botulinum Toxin commonly known as BOTOX®

What is Botulinum Toxin commonly known as BOTOX®?

Botulinum Toxin commonly known as BOTOX® is a Neurotoxin; acetylcholine release inhibitor drug developed by NYU Langone Health, indicated for Cervical dystonia, Blepharospasm, Strabismus.

How does Botulinum Toxin commonly known as BOTOX® work?

Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.

What is Botulinum Toxin commonly known as BOTOX® used for?

Botulinum Toxin commonly known as BOTOX® is indicated for Cervical dystonia, Blepharospasm, Strabismus, Chronic migraine, Hyperhidrosis.

Who makes Botulinum Toxin commonly known as BOTOX®?

Botulinum Toxin commonly known as BOTOX® is developed by NYU Langone Health (see full NYU Langone Health pipeline at /company/nyu-langone-health).

Is Botulinum Toxin commonly known as BOTOX® also known as anything else?

Botulinum Toxin commonly known as BOTOX® is also known as BOTOX®, Saline.

What drug class is Botulinum Toxin commonly known as BOTOX® in?

Botulinum Toxin commonly known as BOTOX® belongs to the Neurotoxin; acetylcholine release inhibitor class. See all Neurotoxin; acetylcholine release inhibitor drugs at /class/neurotoxin-acetylcholine-release-inhibitor.

What development phase is Botulinum Toxin commonly known as BOTOX® in?

Botulinum Toxin commonly known as BOTOX® is in Phase 3.

What are the side effects of Botulinum Toxin commonly known as BOTOX®?

Common side effects of Botulinum Toxin commonly known as BOTOX® include Headache, Neck pain, Muscle weakness, Injection site pain, Flu-like symptoms, Eyelid ptosis.

What does Botulinum Toxin commonly known as BOTOX® target?

Botulinum Toxin commonly known as BOTOX® targets SNARE complex proteins (SNAP-25, VAMP, syntaxin) and is a Neurotoxin; acetylcholine release inhibitor.

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