{"id":"botulinum-toxin-commonly-known-as-botox","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Neck pain"},{"rate":"5-10","effect":"Muscle weakness"},{"rate":"5-10","effect":"Injection site pain"},{"rate":"1-5","effect":"Flu-like symptoms"},{"rate":"1-5","effect":"Eyelid ptosis"},{"rate":"1-5","effect":"Diplopia"}]},"_chembl":{"chemblId":"CHEMBL4297862","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin is a neurotoxin that irreversibly cleaves proteins required for acetylcholine vesicle fusion and release at the presynaptic terminal. This prevents neuromuscular transmission, resulting in flaccid paralysis of the targeted muscle. The effect is temporary, lasting 3-4 months, as the body gradually regenerates the cleaved proteins and forms new neuromuscular junctions.","oneSentence":"Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:41:48.537Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Hyperhidrosis"},{"name":"Spasticity"},{"name":"Facial wrinkles and dynamic expression lines"}]},"trialDetails":[{"nctId":"NCT01422161","phase":"PHASE3","title":"Study of Botulinum Toxin and Recovery of Hand Function After Stroke","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2010-04","conditions":"Stroke With Hemiparesis","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["BOTOX®","Saline"],"phase":"phase_3","status":"active","brandName":"Botulinum Toxin commonly known as BOTOX®","genericName":"Botulinum Toxin commonly known as BOTOX®","companyName":"NYU Langone Health","companyId":"nyu-langone-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}