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Bolus Phenylephrine/Ephedrine Treatment
Phenylephrine and ephedrine are sympathomimetic amines that stimulate alpha and beta adrenergic receptors to increase blood pressure and heart rate.
Phenylephrine and ephedrine are sympathomimetic amines that stimulate alpha and beta adrenergic receptors to increase blood pressure and heart rate. Used for Acute hypotension during anesthesia or critical illness, Perioperative hemodynamic support.
At a glance
| Generic name | Bolus Phenylephrine/Ephedrine Treatment |
|---|---|
| Sponsor | IWK Health Centre |
| Drug class | Sympathomimetic amines / Vasopressors |
| Target | Alpha-1 adrenergic receptor (phenylephrine); Alpha and beta adrenergic receptors (ephedrine) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular / Critical Care |
| Phase | FDA-approved |
Mechanism of action
Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction and increases systemic vascular resistance and blood pressure. Ephedrine is a mixed alpha and beta adrenergic agonist that increases heart rate, contractility, and blood pressure through multiple mechanisms. When administered as a bolus, these agents rapidly restore blood pressure in acute hypotensive states.
Approved indications
- Acute hypotension during anesthesia or critical illness
- Perioperative hemodynamic support
Common side effects
- Hypertension
- Tachycardia
- Arrhythmias
- Headache
- Anxiety
- Tremor
Key clinical trials
- Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery (NA)
- Fluid Therapy and Glycocalyx Shedding During Moderate Surgery (NA)
- Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System (NA)
- Cerebral Oximetry in Single Lung Ventilation Thoracic Surgery (NA)
- Phenylephrine in Spinal Anesthesia in Preeclamptic Patients (NA)
- Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section (PHASE2, PHASE3)
- Prophylactic Phenylephrine Co-administration During Caesarean Section (NA)
- Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bolus Phenylephrine/Ephedrine Treatment CI brief — competitive landscape report
- Bolus Phenylephrine/Ephedrine Treatment updates RSS · CI watch RSS
- IWK Health Centre portfolio CI