{"id":"bolus-phenylephrine-ephedrine-treatment","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Tremor"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction and increases systemic vascular resistance and blood pressure. Ephedrine is a mixed alpha and beta adrenergic agonist that increases heart rate, contractility, and blood pressure through multiple mechanisms. When administered as a bolus, these agents rapidly restore blood pressure in acute hypotensive states.","oneSentence":"Phenylephrine and ephedrine are sympathomimetic amines that stimulate alpha and beta adrenergic receptors to increase blood pressure and heart rate.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:08.964Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute hypotension during anesthesia or critical illness"},{"name":"Perioperative hemodynamic support"}]},"trialDetails":[{"nctId":"NCT05662371","phase":"NA","title":"Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery","status":"RECRUITING","sponsor":"University of Southern Denmark","startDate":"2023-08-01","conditions":"Opioid Use, Unspecified, Pain, Postoperative","enrollment":60},{"nctId":"NCT05939518","phase":"NA","title":"Fluid Therapy and Glycocalyx Shedding During Moderate Surgery","status":"COMPLETED","sponsor":"Hadassah Medical Organization","startDate":"2020-05-13","conditions":"Abdominoplasty","enrollment":51},{"nctId":"NCT03620942","phase":"NA","title":"Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System","status":"ACTIVE_NOT_RECRUITING","sponsor":"KK Women's and Children's Hospital","startDate":"2018-11-07","conditions":"Hypotension, Anesthesia","enrollment":173},{"nctId":"NCT01866657","phase":"NA","title":"Cerebral Oximetry in Single Lung Ventilation Thoracic Surgery","status":"TERMINATED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2013-06","conditions":"Hypoxia","enrollment":74},{"nctId":"NCT00458003","phase":"NA","title":"Phenylephrine in Spinal Anesthesia in Preeclamptic Patients","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2006-07","conditions":"Preeclampsia, Hypotension","enrollment":110},{"nctId":"NCT04025918","phase":"PHASE2, PHASE3","title":"Closed-loop Double-vasopressor Automated System to Treat Hypotension During Spinal Anaesthesia for Caesarean Section","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2011-10","conditions":"Hypotension","enrollment":216},{"nctId":"NCT04005664","phase":"NA","title":"Prophylactic Phenylephrine Co-administration During Caesarean Section","status":"COMPLETED","sponsor":"University of KwaZulu","startDate":"2018-05-01","conditions":"Cesarean Section Complications, Anesthesia Complication","enrollment":300},{"nctId":"NCT03767296","phase":"PHASE4","title":"Influence of a Bolus Administration of Ephedrine and Phenylephrine on the Spinal Oxygen Saturation, Measured With NIRS.","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2017-02-06","conditions":"Influence of Vasoactive Medication on Spinal Oxygenation","enrollment":33},{"nctId":"NCT02428062","phase":"PHASE2, PHASE3","title":"Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly","status":"SUSPENDED","sponsor":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","startDate":"2014-10","conditions":"Post-operative Cognitive Dysfunction","enrollment":1812},{"nctId":"NCT02277730","phase":"PHASE2, PHASE3","title":"A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability","status":"COMPLETED","sponsor":"KK Women's and Children's Hospital","startDate":"2013-05","conditions":"Hypotension","enrollment":252},{"nctId":"NCT02376192","phase":"PHASE4","title":"Maternal Microcirculation & SDF Imaging","status":"COMPLETED","sponsor":"IWK Health Centre","startDate":"2014-01","conditions":"Pregnancy","enrollment":32}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Bolus Phenylephrine/Ephedrine Treatment","genericName":"Bolus Phenylephrine/Ephedrine Treatment","companyName":"IWK Health Centre","companyId":"iwk-health-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phenylephrine and ephedrine are sympathomimetic amines that stimulate alpha and beta adrenergic receptors to increase blood pressure and heart rate. Used for Acute hypotension during anesthesia or critical illness, Perioperative hemodynamic support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}