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Bactrim or Macrobid
Bactrim or Macrobid is a Antibiotic (sulfonamide/trimethoprim combination for Bactrim; nitrofuran for Macrobid) Small molecule drug developed by Ohio State University. It is currently FDA-approved for Urinary tract infections (uncomplicated), Acute cystitis, Bacterial infections (various gram-positive and gram-negative organisms).
Bactrim (sulfamethoxazole-trimethoprim) and Macrobid (nitrofurantoin) are antibiotics that inhibit bacterial nucleotide synthesis and cell wall integrity, respectively, to kill or stop the growth of bacteria.
Bactrim (sulfamethoxazole-trimethoprim) and Macrobid (nitrofurantoin) are antibiotics that inhibit bacterial nucleotide synthesis and cell wall integrity, respectively, to kill or stop the growth of bacteria. Used for Urinary tract infections (uncomplicated), Acute cystitis, Bacterial infections (various gram-positive and gram-negative organisms).
At a glance
| Generic name | Bactrim or Macrobid |
|---|---|
| Sponsor | Ohio State University |
| Drug class | Antibiotic (sulfonamide/trimethoprim combination for Bactrim; nitrofuran for Macrobid) |
| Target | Dihydrofolate reductase (Bactrim); bacterial DNA and enzyme systems (Macrobid) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Bactrim is a combination antibiotic that blocks bacterial folate synthesis by inhibiting dihydrofolate reductase, preventing DNA replication. Macrobid is a nitrofuran antibiotic that damages bacterial DNA and inhibits bacterial enzyme systems. Both are used to treat urinary tract infections and other bacterial infections.
Approved indications
- Urinary tract infections (uncomplicated)
- Acute cystitis
- Bacterial infections (various gram-positive and gram-negative organisms)
Common side effects
- Nausea
- Headache
- Rash
- Diarrhea
- Photosensitivity (Macrobid)
- Peripheral neuropathy (Macrobid, chronic use)
Key clinical trials
- Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid (Bulkamid Study) (PHASE4)
- Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women (PHASE4)
- Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy (PHASE4)
- Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2 (NA)
- Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection (PHASE4)
- Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients (PHASE3)
- Struvite Stones Antibiotic Study (PHASE4)
- Effects of Antibiotic Prophylaxis on Recurrent UTI in Children (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bactrim or Macrobid CI brief — competitive landscape report
- Bactrim or Macrobid updates RSS · CI watch RSS
- Ohio State University portfolio CI
Frequently asked questions about Bactrim or Macrobid
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Related
- Drug class: All Antibiotic (sulfonamide/trimethoprim combination for Bactrim; nitrofuran for Macrobid) drugs
- Target: All drugs targeting Dihydrofolate reductase (Bactrim); bacterial DNA and enzyme systems (Macrobid)
- Manufacturer: Ohio State University — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Urinary tract infections (uncomplicated)
- Indication: Drugs for Acute cystitis
- Indication: Drugs for Bacterial infections (various gram-positive and gram-negative organisms)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing