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Both are used to treat urinary tract infections and other bacterial infections.","oneSentence":"Bactrim (sulfamethoxazole-trimethoprim) and Macrobid (nitrofurantoin) are antibiotics that inhibit bacterial nucleotide synthesis and cell wall integrity, respectively, to kill or stop the growth of bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:42:54.712Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Urinary tract infections (uncomplicated)"},{"name":"Acute cystitis"},{"name":"Bacterial infections (various gram-positive and gram-negative organisms)"}]},"trialDetails":[{"nctId":"NCT06706362","phase":"PHASE4","title":"Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid (Bulkamid Study)","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2025-09-15","conditions":"Stress Urinary Incontinence","enrollment":138},{"nctId":"NCT05726318","phase":"PHASE4","title":"Randomized Trial of 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Used for Urinary tract infections (uncomplicated), Acute cystitis, Bacterial infections (various gram-positive and gram-negative organisms).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}