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Atropine/Remifentanil
This combination pairs atropine (a muscarinic antagonist) with remifentanil (an opioid agonist) to provide anticholinergic and analgesic/sedative effects during anesthesia.
This combination pairs atropine (a muscarinic antagonist) with remifentanil (an opioid agonist) to provide anticholinergic and analgesic/sedative effects during anesthesia. Used for Anesthesia induction and maintenance, Perioperative analgesia and sedation.
At a glance
| Generic name | Atropine/Remifentanil |
|---|---|
| Sponsor | King Saud University |
| Drug class | Anticholinergic/Opioid combination |
| Target | Muscarinic acetylcholine receptor (atropine); mu-opioid receptor (remifentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Atropine blocks muscarinic acetylcholine receptors to reduce secretions and prevent bradycardia, while remifentanil is a potent synthetic opioid that binds mu-opioid receptors to provide rapid-onset analgesia and sedation. Together, they are used as a balanced anesthetic combination, with atropine serving as an adjunct to mitigate opioid-induced side effects such as vagal stimulation.
Approved indications
- Anesthesia induction and maintenance
- Perioperative analgesia and sedation
Common side effects
- Tachycardia
- Dry mouth
- Respiratory depression
- Hypotension
- Bradycardia (if remifentanil predominates)
Key clinical trials
- Intravenous Administration of Magnesium Sulfate in Laparoscopic Hysterectomy Cases (NA)
- Minimal Flow Anesthesia and Infection Risk (NA)
- Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension (NA)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Intravenous Administration of Magnesium Sulfate in Hysterectomy Cases (NA)
- Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
- Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery (NA)
- The Application of Pectoral Nerve II(PECS II)block in Breast Fibroadenoma Resection Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Atropine/Remifentanil CI brief — competitive landscape report
- Atropine/Remifentanil updates RSS · CI watch RSS
- King Saud University portfolio CI