{"id":"atropine-remifentanil","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia (if remifentanil predominates)"}]},"_chembl":{"chemblId":"CHEMBL1201120","moleculeType":"Small molecule","molecularWeight":"412.91"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Atropine blocks muscarinic acetylcholine receptors to reduce secretions and prevent bradycardia, while remifentanil is a potent synthetic opioid that binds mu-opioid receptors to provide rapid-onset analgesia and sedation. Together, they are used as a balanced anesthetic combination, with atropine serving as an adjunct to mitigate opioid-induced side effects such as vagal stimulation.","oneSentence":"This combination pairs atropine (a muscarinic antagonist) with remifentanil (an opioid agonist) to provide anticholinergic and analgesic/sedative effects during anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:19:38.635Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia induction and maintenance"},{"name":"Perioperative analgesia and sedation"}]},"trialDetails":[{"nctId":"NCT05826119","phase":"NA","title":"Intravenous Administration of Magnesium Sulfate in Laparoscopic Hysterectomy Cases","status":"COMPLETED","sponsor":"Ondokuz Mayıs University","startDate":"2024-01-20","conditions":"Laparoscopic Hysterectomy, Magnesium Sulfate, General Anesthesia","enrollment":60},{"nctId":"NCT07092046","phase":"NA","title":"Minimal Flow Anesthesia and Infection Risk","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ankara City Hospital Bilkent","startDate":"2025-07-01","conditions":"Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia","enrollment":140},{"nctId":"NCT07064434","phase":"NA","title":"Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension","status":"RECRUITING","sponsor":"General Hospital of Ningxia Medical University","startDate":"2024-11-01","conditions":"Postoperative Pain","enrollment":80},{"nctId":"NCT07033442","phase":"NA","title":"Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery","status":"COMPLETED","sponsor":"Ataturk Training and Research Hospital","startDate":"2015-07-23","conditions":"Anaesthesia, Intraocular Pressure, Trendelenburg Position","enrollment":60},{"nctId":"NCT05644873","phase":"NA","title":"Intravenous Administration of Magnesium Sulfate in Hysterectomy Cases","status":"COMPLETED","sponsor":"Ondokuz Mayıs University","startDate":"2023-11-15","conditions":"Abdominal Hysterectomy, General Anesthesia, Magnesium Sulfate","enrollment":48},{"nctId":"NCT06683911","phase":"","title":"Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2024-04-03","conditions":"Undergoing Open-Heart Surgery","enrollment":98},{"nctId":"NCT05411159","phase":"NA","title":"Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery","status":"COMPLETED","sponsor":"Beijing Chao Yang Hospital","startDate":"2022-06-07","conditions":"Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases","enrollment":168},{"nctId":"NCT06608810","phase":"NA","title":"The Application of Pectoral Nerve II(PECS II)block in Breast Fibroadenoma Resection Surgery","status":"COMPLETED","sponsor":"Inner Mongolia Baogang Hospital","startDate":"2023-07-30","conditions":"Breast Neoplasms","enrollment":90},{"nctId":"NCT01871922","phase":"NA","title":"Atropine-effect During Propofol/Remifentanil Induction","status":"COMPLETED","sponsor":"University Medical Center Groningen","startDate":"2012-10","conditions":"Anesthesia-induced Negative Hemodynamic Effects","enrollment":60},{"nctId":"NCT05769842","phase":"NA","title":"Effects of Propofol on Respiratory Adverse Events During Extubation in Children Undergoing Tonsil Adenoidectomy","status":"COMPLETED","sponsor":"Children's Hospital of Fudan University","startDate":"2023-11-01","conditions":"Airway Complication of Anesthesia","enrollment":239},{"nctId":"NCT05004519","phase":"NA","title":"Benefits of Opioid Free Anesthesia on Morphine Consumption in Gastric Bypass","status":"COMPLETED","sponsor":"matthieu clanet","startDate":"2021-10-05","conditions":"Analgesics, Opioid","enrollment":183},{"nctId":"NCT06130527","phase":"NA","title":"Comparison of the Effects of Nicardipine and Remifentanil on Surgical Visual Field","status":"UNKNOWN","sponsor":"Erol Karaaslan","startDate":"2023-11-30","conditions":"Other Complications of Surgical and Medical Procedures","enrollment":64},{"nctId":"NCT02164734","phase":"PHASE4","title":"Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome","status":"TERMINATED","sponsor":"Albany Medical College","startDate":"2014-06","conditions":"Respiratory Distress Syndrome, Newborn","enrollment":93},{"nctId":"NCT04087668","phase":"NA","title":"Different Anesthetic Technique For ERCP","status":"COMPLETED","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2019-09-01","conditions":"Anesthesia; Adverse Effect","enrollment":405},{"nctId":"NCT04002271","phase":"PHASE4","title":"Total Knee Replacement TIVA With Robotic Arm Assisted","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2020-07-22","conditions":"Postoperative Pain","enrollment":180},{"nctId":"NCT05785273","phase":"","title":"Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2019-02-19","conditions":"Analgesia, Anesthesia","enrollment":45},{"nctId":"NCT04073758","phase":"NA","title":"Comparison of Analgesic Requirements in Patients Receiving Nuss Operation Using 2 Different Anesthetic Adjuvants","status":"UNKNOWN","sponsor":"Jung Min Koo","startDate":"2019-09-02","conditions":"Chest Wall Disorder","enrollment":62},{"nctId":"NCT03131375","phase":"PHASE2, PHASE3","title":"Dexmedetomidine Reduces Emergence Delirium in Children Undergoing Tonsillectomy With Propofol Anesthesia","status":"COMPLETED","sponsor":"Athens General Children's Hospital \"Pan. & Aglaia Kyriakou\"","startDate":"2017-05-01","conditions":"Emergence Delirium, Extubation Time, Heart Rate","enrollment":60},{"nctId":"NCT02763098","phase":"PHASE4","title":"Remifentanil on Hemodynamic Response to Anesthesia Induction","status":"COMPLETED","sponsor":"Dokuz Eylul University","startDate":"2012-01","conditions":"Anesthesia","enrollment":90},{"nctId":"NCT01966484","phase":"NA","title":"Low Dose Mivacurium vs. Low Dose Succinylcholine for Rigid Bronchoscopy","status":"COMPLETED","sponsor":"Dr. Horst Schmidt Klinik GmbH","startDate":"2013-10","conditions":"Intubating Conditions, Performance With Respiratory Exercise Device, Postoperative Myalgia","enrollment":100},{"nctId":"NCT01651572","phase":"PHASE4","title":"Comparison Between Cisatracurium and Rocuronium in Terms of Recovery of the Muscular Strength in the Postoperative Phase After Surgery and General Anaesthesia","status":"COMPLETED","sponsor":"Azienda Ospedaliera di Padova","startDate":"2012-07","conditions":"Postoperative Residual Curarization, Residual Neuromuscular Block","enrollment":120},{"nctId":"NCT01871935","phase":"NA","title":"Atropine Effects in Anaesthesia With Sufentanil vs. Remifentanil","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2013-06","conditions":"Haemodynamic Fluctuations During Off-pump CABG.","enrollment":70},{"nctId":"NCT00216944","phase":"PHASE4","title":"Balanced Anesthesia for Intubation of Premature Infants","status":"COMPLETED","sponsor":"Lund University Hospital","startDate":"2005-08","conditions":"Premature Birth","enrollment":40},{"nctId":"NCT00815048","phase":"PHASE4","title":"Remifentanil and Atropine for Intubation in Neonates","status":"COMPLETED","sponsor":"King Saud University","startDate":"2006-01","conditions":"Endotracheal Intubation","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":100,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Atropine/Remifentanil","genericName":"Atropine/Remifentanil","companyName":"King Saud University","companyId":"king-saud-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination pairs atropine (a muscarinic antagonist) with remifentanil (an opioid agonist) to provide anticholinergic and analgesic/sedative effects during anesthesia. Used for Anesthesia induction and maintenance, Perioperative analgesia and sedation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}